Autoimmune hepatitis Diagnostic of choice: Difference between revisions
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Histology findings usually found on biopsy: | Histology findings usually found on biopsy: | ||
*Interface hepatitis (ie, piecemeal necrosis) is the histological hallmark | *Interface hepatitis (ie, piecemeal necrosis) is the histological hallmark | ||
**Portal lesion spares the biliary tree | |||
**This involves most of the lobule. | |||
**Lobular collapse which is best identified by reticulin staining | |||
**There is lymphoplasmacytic periportal infiltrate which invade the limiting plate | **There is lymphoplasmacytic periportal infiltrate which invade the limiting plate | ||
**There is an abundance of plasma cells and eosinophils are usually present | **There is an abundance of plasma cells and eosinophils are usually present | ||
*A plasma cell infiltrate lead to plasma cell hepatitis If it involves lobules called lobular or whole liver known as panacinar hepatitis | |||
*A plasma cell infiltrate lead to plasma cell hepatitis | |||
*Fibrosis causes distortion of the hepatic lobule and the appearance of regenerative nodules, resulting in cirrhosis | *Fibrosis causes distortion of the hepatic lobule and the appearance of regenerative nodules, resulting in cirrhosis | ||
*Bridging necrosis is a finding seen in cirrhosis | *Bridging necrosis is a finding seen in cirrhosis | ||
Revision as of 03:48, 20 December 2017
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Autoimmune hepatitis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Autoimmune hepatitis Diagnostic of choice On the Web |
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American Roentgen Ray Society Images of Autoimmune hepatitis Diagnostic of choice |
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Risk calculators and risk factors for Autoimmune hepatitis Diagnostic of choice |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Diagnostic Study of Choice
Gold standard/Study of choice:
- Liver biopsy is the gold standard test for the diagnosis of Autoimmune hepatitis
- Liver biopsy is performed by following methods:
- Percutaneous liver biopsy with or without ultrasound guidance
- Transjugular liver biopsy
Histology findings usually found on biopsy:
- Interface hepatitis (ie, piecemeal necrosis) is the histological hallmark
- Portal lesion spares the biliary tree
- This involves most of the lobule.
- Lobular collapse which is best identified by reticulin staining
- There is lymphoplasmacytic periportal infiltrate which invade the limiting plate
- There is an abundance of plasma cells and eosinophils are usually present
- A plasma cell infiltrate lead to plasma cell hepatitis If it involves lobules called lobular or whole liver known as panacinar hepatitis
- Fibrosis causes distortion of the hepatic lobule and the appearance of regenerative nodules, resulting in cirrhosis
- Bridging necrosis is a finding seen in cirrhosis