Autoimmune hepatitis Diagnostic of choice: Difference between revisions
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*Fibrosis causes distortion of the hepatic lobule and the appearance of regenerative nodules, resulting in cirrhosis | *Fibrosis causes distortion of the hepatic lobule and the appearance of regenerative nodules, resulting in cirrhosis | ||
*Bridging necrosis is a finding seen in cirrhosis | *Bridging necrosis is a finding seen in cirrhosis | ||
==Overlap syndrome== | |||
==References== | ==References== |
Revision as of 02:34, 31 December 2017
Autoimmune hepatitis Microchapters |
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Autoimmune hepatitis Diagnostic of choice On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Diagnostic Study of Choice
Gold standard/Study of choice:
- Liver biopsy is the gold standard test for the diagnosis of Autoimmune hepatitis
- Liver biopsy is performed by following methods:
- Percutaneous liver biopsy with or without ultrasound guidance
- Transjugular liver biopsy
Histology findings usually found on biopsy:
- Interface hepatitis (ie, piecemeal necrosis) is the histological hallmark
- Portal lesion spares the biliary tree
- This involves most of the lobule.
- Lobular collapse which is best identified by reticulin staining
- There is lymphoplasmacytic periportal infiltrate which invade the limiting plate
- There is an abundance of plasma cells and eosinophils are usually present
- A plasma cell infiltrate lead to plasma cell hepatitis If it involves lobules called lobular or whole liver known as panacinar hepatitis
- Fibrosis causes distortion of the hepatic lobule and the appearance of regenerative nodules, resulting in cirrhosis
- Bridging necrosis is a finding seen in cirrhosis