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{{Infobox_gene}}
{{Infobox_gene}}
'''ERBB receptor feedback inhibitor 1''' is a [[protein]] that in humans is encoded by the ''ERRFI1'' [[gene]].<ref name="pmid10749885">{{cite journal | vauthors = Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM | title = Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress | journal = J Biol Chem | volume = 275 | issue = 23 | pages = 17838–17847 |date=Jul 2000 | pmid = 10749885 | pmc =  | doi = 10.1074/jbc.M909735199 }}</ref><ref name="pmid2780291">{{cite journal | vauthors = Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK | title = Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity | journal = Nucleic Acids Res | volume = 17 | issue = 16 | pages = 6651–6667 |date=Oct 1989 | pmid = 2780291 | pmc = 318357 | doi =10.1093/nar/17.16.6651  }}</ref><ref name="pmid12226756">{{cite journal | vauthors = Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O | title = Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control | journal = Oncogene | volume = 21 | issue = 42 | pages = 6530–6539 |date=Sep 2002 | pmid = 12226756 | pmc =  | doi = 10.1038/sj.onc.1205823 }}</ref><ref name="pmid11003669">{{cite journal | vauthors = Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O | title = Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain | journal = Mol Cell Biol | volume = 20 | issue = 20 | pages = 7735–7750 |date=Oct 2000 | pmid = 11003669 | pmc = 86354 | doi =10.1128/MCB.20.20.7735-7750.2000  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54206| accessdate = }}</ref>
'''ERBB receptor feedback inhibitor 1''' is a [[protein]] that in humans is encoded by the ''ERRFI1'' [[gene]].<ref name="pmid10749885">{{cite journal | vauthors = Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM | title = Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress | journal = J Biol Chem | volume = 275 | issue = 23 | pages = 17838–17847 |date=Jul 2000 | pmid = 10749885 | pmc =  3668664| doi = 10.1074/jbc.M909735199 }}</ref><ref name="pmid2780291">{{cite journal | vauthors = Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK | title = Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity | journal = Nucleic Acids Res | volume = 17 | issue = 16 | pages = 6651–6667 |date=Oct 1989 | pmid = 2780291 | pmc = 318357 | doi =10.1093/nar/17.16.6651  }}</ref><ref name="pmid12226756">{{cite journal | vauthors = Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O | title = Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control | journal = Oncogene | volume = 21 | issue = 42 | pages = 6530–6539 |date=Sep 2002 | pmid = 12226756 | pmc =  | doi = 10.1038/sj.onc.1205823 }}</ref><ref name="pmid11003669">{{cite journal | vauthors = Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O | title = Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain | journal = Mol Cell Biol | volume = 20 | issue = 20 | pages = 7735–7750 |date=Oct 2000 | pmid = 11003669 | pmc = 86354 | doi =10.1128/MCB.20.20.7735-7750.2000  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54206| accessdate = }}</ref>


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*{{cite journal  | author=Tsunoda T |title=A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6 |journal=Cancer Res. |volume=62 |issue= 20 |pages= 5668–71 |year= 2002 |pmid= 12384522 |doi=  |name-list-format=vanc| author2=Inokuchi J  | author3=Baba I  | display-authors=3  | last4=Okumura  | first4=K  | last5=Naito  | first5=S  | last6=Sasazuki  | first6=T  | last7=Shirasawa  | first7=S  }}
*{{cite journal  | author=Tsunoda T |title=A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6 |journal=Cancer Res. |volume=62 |issue= 20 |pages= 5668–71 |year= 2002 |pmid= 12384522 |doi=  |name-list-format=vanc| author2=Inokuchi J  | author3=Baba I  | display-authors=3  | last4=Okumura  | first4=K  | last5=Naito  | first5=S  | last6=Sasazuki  | first6=T  | last7=Shirasawa  | first7=S  }}
*{{cite journal  | vauthors=Saarikoski ST, Rivera SP, Hankinson O |title=Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia |journal=FEBS Lett. |volume=530 |issue= 1–3 |pages= 186–190 |year= 2002 |pmid= 12387890 |doi=10.1016/S0014-5793(02)03475-0  }}
*{{cite journal  | vauthors=Saarikoski ST, Rivera SP, Hankinson O |title=Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia |journal=FEBS Lett. |volume=530 |issue= 1–3 |pages= 186–190 |year= 2002 |pmid= 12387890 |doi=10.1016/S0014-5793(02)03475-0  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal  | author=Anastasi S |title=Feedback inhibition by RALT controls signal output by the ErbB network |journal=Oncogene |volume=22 |issue= 27 |pages= 4221–4234 |year= 2003 |pmid= 12833145 |doi= 10.1038/sj.onc.1206516  |name-list-format=vanc| author2=Fiorentino L  | author3=Fiorini M  | display-authors=3  | last4=Fraioli  | first4=Rocco  | last5=Sala  | first5=Gianluca  | last6=Castellani  | first6=L  | last7=Alemà  | first7=Stefano  | last8=Alimandi  | first8=Maurizio  | last9=Segatto  | first9=Oreste }}
*{{cite journal  | author=Anastasi S |title=Feedback inhibition by RALT controls signal output by the ErbB network |journal=Oncogene |volume=22 |issue= 27 |pages= 4221–4234 |year= 2003 |pmid= 12833145 |doi= 10.1038/sj.onc.1206516  |name-list-format=vanc| author2=Fiorentino L  | author3=Fiorini M  | display-authors=3  | last4=Fraioli  | first4=Rocco  | last5=Sala  | first5=Gianluca  | last6=Castellani  | first6=L  | last7=Alemà  | first7=Stefano  | last8=Alimandi  | first8=Maurizio  | last9=Segatto  | first9=Oreste }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
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*{{cite journal  | author=Anastasi S |title=Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin |journal=Oncogene |volume=24 |issue= 28 |pages= 4540–4548 |year= 2005 |pmid= 15856022 |doi= 10.1038/sj.onc.1208658  |name-list-format=vanc| author2=Sala G  | author3=Huiping C  | display-authors=3  | last4=Caprini  | first4=Elisabetta  | last5=Russo  | first5=Giandomenico  | last6=Iacovelli  | first6=Stefano  | last7=Lucini  | first7=Fabiana  | last8=Ingvarsson  | first8=Sigurdur  | last9=Segatto  | first9=Oreste }}
*{{cite journal  | author=Anastasi S |title=Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin |journal=Oncogene |volume=24 |issue= 28 |pages= 4540–4548 |year= 2005 |pmid= 15856022 |doi= 10.1038/sj.onc.1208658  |name-list-format=vanc| author2=Sala G  | author3=Huiping C  | display-authors=3  | last4=Caprini  | first4=Elisabetta  | last5=Russo  | first5=Giandomenico  | last6=Iacovelli  | first6=Stefano  | last7=Lucini  | first7=Fabiana  | last8=Ingvarsson  | first8=Sigurdur  | last9=Segatto  | first9=Oreste }}
*{{cite journal  | author=Ballarò C |title=Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype |journal=EMBO Rep. |volume=6 |issue= 8 |pages= 755–761 |year= 2006 |pmid= 16007071 |doi= 10.1038/sj.embor.7400458  | pmc=1369136  |name-list-format=vanc| author2=Ceccarelli S  | author3=Tiveron C  | display-authors=3  | last4=Tatangelo  | first4=Laura  | last5=Salvatore  | first5=Anna Maria  | last6=Segatto  | first6=Oreste  | last7=Alemà  | first7=Stefano }}
*{{cite journal  | author=Ballarò C |title=Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype |journal=EMBO Rep. |volume=6 |issue= 8 |pages= 755–761 |year= 2006 |pmid= 16007071 |doi= 10.1038/sj.embor.7400458  | pmc=1369136  |name-list-format=vanc| author2=Ceccarelli S  | author3=Tiveron C  | display-authors=3  | last4=Tatangelo  | first4=Laura  | last5=Salvatore  | first5=Anna Maria  | last6=Segatto  | first6=Oreste  | last7=Alemà  | first7=Stefano }}
*{{cite journal  | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–321 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727  |name-list-format=vanc| author2=Barlow KF  | author3=McLay KE  | display-authors=3  | last4=Kaul  | first4=R.  | last5=Swarbreck  | first5=D.  | last6=Dunham  | first6=A.  | last7=Scott  | first7=C. E.  | last8=Howe  | first8=K. L.  | last9=Woodfine  | first9=K. }}
*{{cite journal  | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–321 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727  |name-list-format=vanc| author2=Barlow KF  | author3=McLay KE  | display-authors=3  | last4=Kaul  | first4=R.  | last5=Swarbreck  | first5=D.  | last6=Dunham  | first6=A.  | last7=Scott  | first7=C. E.  | last8=Howe  | first8=K. L.  | last9=Woodfine  | first9=K. |bibcode=2006Natur.441..315G}}
*{{cite journal  | author=Zhang YW |title=Evidence that MIG-6 is a tumor-suppressor gene |journal=Oncogene |volume=26 |issue= 2 |pages= 269–276 |year= 2007 |pmid= 16819504 |doi= 10.1038/sj.onc.1209790  |name-list-format=vanc| author2=Staal B  | author3=Su Y  | display-authors=3  | last4=Swiatek  | first4=P  | last5=Zhao  | first5=P  | last6=Cao  | first6=B  | last7=Resau  | first7=J  | last8=Sigler  | first8=R  | last9=Bronson  | first9=R }}
*{{cite journal  | author=Zhang YW |title=Evidence that MIG-6 is a tumor-suppressor gene |journal=Oncogene |volume=26 |issue= 2 |pages= 269–276 |year= 2007 |pmid= 16819504 |doi= 10.1038/sj.onc.1209790  |name-list-format=vanc| author2=Staal B  | author3=Su Y  | display-authors=3  | last4=Swiatek  | first4=P  | last5=Zhao  | first5=P  | last6=Cao  | first6=B  | last7=Resau  | first7=J  | last8=Sigler  | first8=R  | last9=Bronson  | first9=R }}
}}
}}

Latest revision as of 10:17, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.[1][2][3][4][5]

MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM][5]

Interactions

ERRFI1 has been shown to interact with Stratifin[6] and CDC42.[1]

References

  1. ↑ 1.0 1.1 Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (Jul 2000). "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". J Biol Chem. 275 (23): 17838–17847. doi:10.1074/jbc.M909735199. PMC 3668664. PMID 10749885.
  2. ↑ Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK (Oct 1989). "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Res. 17 (16): 6651–6667. doi:10.1093/nar/17.16.6651. PMC 318357. PMID 2780291.
  3. ↑ Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O (Sep 2002). "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene. 21 (42): 6530–6539. doi:10.1038/sj.onc.1205823. PMID 12226756.
  4. ↑ Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O (Oct 2000). "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Mol Cell Biol. 20 (20): 7735–7750. doi:10.1128/MCB.20.20.7735-7750.2000. PMC 86354. PMID 11003669.
  5. ↑ 5.0 5.1 "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1".
  6. ↑ Benzinger, Anne; Muster Nemone; Koch Heike B; Yates John R; Hermeking Heiko (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. United States. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. ISSN 1535-9476. PMID 15778465.

Further reading



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