ATG4A: Difference between revisions
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*{{cite journal | vauthors=Scherz-Shouval R, Shvets E, Fass E |title=Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 | *{{cite journal | vauthors=Scherz-Shouval R, Shvets E, Fass E |title=Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 |journal=EMBO J. |volume=26 |issue= 7 |pages= 1749–60 |year= 2007 |pmid= 17347651 |doi= 10.1038/sj.emboj.7601623 | pmc=1847657 |display-authors=etal}} | ||
*{{cite journal | vauthors=Ross MT, Grafham DV, Coffey AJ |title=The DNA sequence of the human X chromosome | *{{cite journal | vauthors=Ross MT, Grafham DV, Coffey AJ |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |display-authors=etal}} | ||
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | vauthors=Kabeya Y, Mizushima N, Yamamoto A |title=LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation | *{{cite journal | vauthors=Kabeya Y, Mizushima N, Yamamoto A |title=LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation |journal=J. Cell Sci. |volume=117 |issue= Pt 13 |pages= 2805–12 |year= 2005 |pmid= 15169837 |doi= 10.1242/jcs.01131 |display-authors=etal}} | ||
*{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs | *{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}} | ||
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
Latest revision as of 22:51, 5 September 2018
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| Location (UCSC) | n/a | n/a | |||||
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Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.[1][2][3]
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.[3]
References
- ↑ Marino G, Uria JA, Puente XS, Quesada V, Bordallo J, Lopez-Otin C (Feb 2003). "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy". J Biol Chem. 278 (6): 3671–8. doi:10.1074/jbc.M208247200. PMID 12446702.
- ↑ Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J Biol Chem. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.
- ↑ 3.0 3.1 "Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)".
External links
- Human ATG4A genome location and ATG4A gene details page in the UCSC Genome Browser.
Further reading
- Scherz-Shouval R, Shvets E, Fass E, et al. (2007). "Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4". EMBO J. 26 (7): 1749–60. doi:10.1038/sj.emboj.7601623. PMC 1847657. PMID 17347651.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kabeya Y, Mizushima N, Yamamoto A, et al. (2005). "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation". J. Cell Sci. 117 (Pt 13): 2805–12. doi:10.1242/jcs.01131. PMID 15169837.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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