Autoimmune hepatitis natural history, complications and prognosis: Difference between revisions
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===Complications=== | ===Complications=== | ||
Common complications of Autoimmune hepatitis include:<ref name="pmid23634279">{{cite journal |vauthors=Trivedi PJ, Hirschfield GM |title=Treatment of autoimmune liver disease: current and future therapeutic options |journal=Ther Adv Chronic Dis |volume=4 |issue=3 |pages=119–41 |year=2013 |pmid=23634279 |pmc=3629750 |doi=10.1177/2040622313478646 |url=}}</ref> | Common complications of Autoimmune hepatitis include:<ref name="pmid23634279">{{cite journal |vauthors=Trivedi PJ, Hirschfield GM |title=Treatment of autoimmune liver disease: current and future therapeutic options |journal=Ther Adv Chronic Dis |volume=4 |issue=3 |pages=119–41 |year=2013 |pmid=23634279 |pmc=3629750 |doi=10.1177/2040622313478646 |url=}}</ref><ref name="pmid21757447">{{cite journal |vauthors=Gleeson D, Heneghan MA |title=British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitis |journal=Gut |volume=60 |issue=12 |pages=1611–29 |year=2011 |pmid=21757447 |doi=10.1136/gut.2010.235259 |url=}}</ref> | ||
*Cirrhosis and complications of cirrhosis | *Cirrhosis and complications of cirrhosis | ||
**Ascites | **Ascites | ||
Revision as of 17:20, 21 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Natural History=
- The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
- The symptoms of (disease name) typically develop ___ years after exposure to ___.
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
Common complications of Autoimmune hepatitis include:[1][2]
- Cirrhosis and complications of cirrhosis
- Ascites
- Coagulopathy
- Liver failure
- Hepatocellular carcinoma
- Hepatic encephalopathy
- Portal hypertension
- Esophageal varices
- Metabolic bone disease
- Hyperlipidaemia
- Hypovitaminosis of cholestasis
- Pruritis of cholestasis
Prognosis
- Prognosis is generally excellent, and the 10-year survival rate of patients with Autoimmune hepatitis treated with immunosuppressive therapy is approximately 80%.[3][4]
- Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis
References
- ↑ Trivedi PJ, Hirschfield GM (2013). "Treatment of autoimmune liver disease: current and future therapeutic options". Ther Adv Chronic Dis. 4 (3): 119–41. doi:10.1177/2040622313478646. PMC 3629750. PMID 23634279.
- ↑ Gleeson D, Heneghan MA (2011). "British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitis". Gut. 60 (12): 1611–29. doi:10.1136/gut.2010.235259. PMID 21757447.
- ↑ Hoeroldt B, McFarlane E, Dube A, Basumani P, Karajeh M, Campbell MJ, Gleeson D (2011). "Long-term outcomes of patients with autoimmune hepatitis managed at a nontransplant center". Gastroenterology. 140 (7): 1980–9. doi:10.1053/j.gastro.2011.02.065. PMID 21396370.
- ↑ D'Amico G, Garcia-Tsao G, Pagliaro L (2006). "Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies". J. Hepatol. 44 (1): 217–31. doi:10.1016/j.jhep.2005.10.013. PMID 16298014.