Autoimmune hepatitis risk factors: Difference between revisions
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*Females: | *Females: | ||
**Autoimmune hepatitis is more common in young females | **Autoimmune hepatitis is more common in young females | ||
*Genetic predisposition: | *Genetic predisposition:<ref name="pmid15288484">{{cite journal |vauthors=Donaldson PT |title=Genetics of autoimmune and viral liver diseases; understanding the issues |journal=J. Hepatol. |volume=41 |issue=2 |pages=327–32 |year=2004 |pmid=15288484 |doi=10.1016/j.jhep.2004.06.001 |url=}}</ref> | ||
**Autoimmune hepatitis type 1 has the association with HLA-DR3 and HLA-DR4 | **Autoimmune hepatitis type 1 has the association with HLA-DR3 and HLA-DR4 | ||
**Type 2 AIH has an association with the HLA-DQB1 and HLA-DRB1 alleles | **Type 2 AIH has an association with the HLA-DQB1 and HLA-DRB1 alleles | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Risk Factors
Common Risk Factors
Common risk factors in the development of Autoimmune hepatitis include:
- Females:
- Autoimmune hepatitis is more common in young females
- Genetic predisposition:[1]
- Autoimmune hepatitis type 1 has the association with HLA-DR3 and HLA-DR4
- Type 2 AIH has an association with the HLA-DQB1 and HLA-DRB1 alleles
- History of another autoimmune disease:
- Autoimmune diseases, including thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis
Less Common Risk Factors
Less common risk factors in the development of Autoimmune hepatitis include:
- A history of viral infections:[2][3]
- Autoimmune hepatitis is common who are infected with the measles, herpes simplex or Epstein-Barr virus and hepatitis A, B or C infection in the past.
- History of drug intake:
- Minocycline, Nitrofurantoin, Hydralazine, Methyldopa Statins, Fenofibrate, Interferon, Infliximab, Etanercept increases the risk of autoimmune hepatitis
References
- ↑ Donaldson PT (2004). "Genetics of autoimmune and viral liver diseases; understanding the issues". J. Hepatol. 41 (2): 327–32. doi:10.1016/j.jhep.2004.06.001. PMID 15288484.
- ↑ Vento S, Cainelli F (2004). "Is there a role for viruses in triggering autoimmune hepatitis?". Autoimmun Rev. 3 (1): 61–9. doi:10.1016/S1568-9972(03)00053-3. PMID 14871651.
- ↑ Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH (1995). "Autoimmune hepatitis following hepatitis A virus infection". J. Hepatol. 23 (2): 204–8. PMID 7499793.