Autoimmune hepatitis risk factors: Difference between revisions
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*A history of [[viral infections]]:<ref name="pmid14871651">{{cite journal |vauthors=Vento S, Cainelli F |title=Is there a role for viruses in triggering autoimmune hepatitis? |journal=Autoimmun Rev |volume=3 |issue=1 |pages=61–9 |year=2004 |pmid=14871651 |doi=10.1016/S1568-9972(03)00053-3 |url=}}</ref><ref name="pmid7499793">{{cite journal |vauthors=Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH |title=Autoimmune hepatitis following hepatitis A virus infection |journal=J. Hepatol. |volume=23 |issue=2 |pages=204–8 |year=1995 |pmid=7499793 |doi= |url=}}</ref> | *A history of [[viral infections]]:<ref name="pmid14871651">{{cite journal |vauthors=Vento S, Cainelli F |title=Is there a role for viruses in triggering autoimmune hepatitis? |journal=Autoimmun Rev |volume=3 |issue=1 |pages=61–9 |year=2004 |pmid=14871651 |doi=10.1016/S1568-9972(03)00053-3 |url=}}</ref><ref name="pmid7499793">{{cite journal |vauthors=Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH |title=Autoimmune hepatitis following hepatitis A virus infection |journal=J. Hepatol. |volume=23 |issue=2 |pages=204–8 |year=1995 |pmid=7499793 |doi= |url=}}</ref> | ||
**Autoimmune hepatitis is common who are infected with the [[measles]], [[herpes simplex]] or [[Epstein Barr virus|epstein-Barr virus]] and [[hepatitis A]], B or C infection in the past. | **Autoimmune hepatitis is common who are infected with the [[measles]], [[herpes simplex]] or [[Epstein Barr virus|epstein-Barr virus]] and [[hepatitis A]], B or C infection in the past. | ||
*History of drug intake: | *History of drug intake:<ref name="pmid20512992">{{cite journal |vauthors=Björnsson E, Talwalkar J, Treeprasertsuk S, Kamath PS, Takahashi N, Sanderson S, Neuhauser M, Lindor K |title=Drug-induced autoimmune hepatitis: clinical characteristics and prognosis |journal=Hepatology |volume=51 |issue=6 |pages=2040–8 |year=2010 |pmid=20512992 |doi=10.1002/hep.23588 |url=}}</ref> | ||
**[[Minocycline]], [[Nitrofurantoin]], [[Hydralazine]], [[Methyldopa]] [[Statins]], [[Fenofibrate]], [[Interferon]], [[Infliximab]], [[Etanercept]] increases the risk of autoimmune hepatitis | **[[Minocycline]], [[Nitrofurantoin]], [[Hydralazine]], [[Methyldopa]] [[Statins]], [[Fenofibrate]], [[Interferon]], [[Infliximab]], [[Etanercept]] increases the risk of autoimmune hepatitis | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Common risk factors in the development of Autoimmune hepatitis include female gender, Genetic predisposition associated with HLADR3 and HLADR4, and History of other autoimmune hepatitis eg thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis.
Risk Factors
Common Risk Factors
Common risk factors in the development of Autoimmune hepatitis include:
- Females:
- Autoimmune hepatitis is more common in young females
- Genetic predisposition:[1]
- Autoimmune hepatitis type 1 has the association with HLA-DR3 and HLA-DR4
- Type 2 AIH has an association with the HLA-DQB1 and HLA-DRB1 alleles
- History of another autoimmune disease:[2]
- Autoimmune diseases, including thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis
Less Common Risk Factors
Less common risk factors in the development of Autoimmune hepatitis include:
- A history of viral infections:[3][4]
- Autoimmune hepatitis is common who are infected with the measles, herpes simplex or epstein-Barr virus and hepatitis A, B or C infection in the past.
- History of drug intake:[5]
- Minocycline, Nitrofurantoin, Hydralazine, Methyldopa Statins, Fenofibrate, Interferon, Infliximab, Etanercept increases the risk of autoimmune hepatitis
References
- ↑ Donaldson PT (2004). "Genetics of autoimmune and viral liver diseases; understanding the issues". J. Hepatol. 41 (2): 327–32. doi:10.1016/j.jhep.2004.06.001. PMID 15288484.
- ↑ "Autoimmune hepatitis - PubMed Health". Retrieved 2013-01-02.
- ↑ Vento S, Cainelli F (2004). "Is there a role for viruses in triggering autoimmune hepatitis?". Autoimmun Rev. 3 (1): 61–9. doi:10.1016/S1568-9972(03)00053-3. PMID 14871651.
- ↑ Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH (1995). "Autoimmune hepatitis following hepatitis A virus infection". J. Hepatol. 23 (2): 204–8. PMID 7499793.
- ↑ Björnsson E, Talwalkar J, Treeprasertsuk S, Kamath PS, Takahashi N, Sanderson S, Neuhauser M, Lindor K (2010). "Drug-induced autoimmune hepatitis: clinical characteristics and prognosis". Hepatology. 51 (6): 2040–8. doi:10.1002/hep.23588. PMID 20512992.