Colon polyps natural history, complications and prognosis: Difference between revisions
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===Natural History=== | ===Natural History=== | ||
*Colon polyps are very common in general population. | *Colon polyps are very common in general population.<ref name="HuangFarraye2010">{{cite journal|last1=Huang|first1=Christopher S|last2=Farraye|first2=Francis A|last3=Yang|first3=Shi|last4=O'Brien|first4=Michael J|title=The Clinical Significance of Serrated Polyps|journal=The American Journal of Gastroenterology|volume=106|issue=2|year=2010|pages=229–240|issn=0002-9270|doi=10.1038/ajg.2010.429}}</ref> | ||
*They are usually found during screening [[colonoscopy]]. | *They are usually found during screening [[colonoscopy]].<ref name="Bonnington2016">{{cite journal|last1=Bonnington|first1=Stewart N|title=Surveillance of colonic polyps: Are we getting it right?|journal=World Journal of Gastroenterology|volume=22|issue=6|year=2016|pages=1925|issn=1007-9327|doi=10.3748/wjg.v22.i6.1925}}</ref> | ||
*Polyps might grow and cause symptoms including [[obstruction]], [[bleeding]], and changes in bowel habits. | *Polyps might grow and cause symptoms including [[obstruction]], [[bleeding]], and changes in bowel habits. | ||
*Some of them might have [[malignant]] potential. | *Some of them might have [[malignant]] potential. | ||
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===Complications=== | ===Complications=== | ||
*Common complications of colon polyps include: | *Common complications of colon polyps include:<ref name="Bonnington2016">{{cite journal|last1=Bonnington|first1=Stewart N|title=Surveillance of colonic polyps: Are we getting it right?|journal=World Journal of Gastroenterology|volume=22|issue=6|year=2016|pages=1925|issn=1007-9327|doi=10.3748/wjg.v22.i6.1925}}</ref><ref name="ShussmanWexner2014">{{cite journal|last1=Shussman|first1=N.|last2=Wexner|first2=S. D.|title=Colorectal polyps and polyposis syndromes|journal=Gastroenterology Report|volume=2|issue=1|year=2014|pages=1–15|issn=2052-0034|doi=10.1093/gastro/got041}}</ref> | ||
**[[Colorectal cancer]] | **[[Colorectal cancer]] | ||
**[[Gastrointestinal bleeding]] | **[[Gastrointestinal bleeding]] | ||
**[[Bleeding]] following [[polypectomy]] | |||
===Prognosis=== | ===Prognosis=== | ||
*Prognosis of colon polyps is generally excellent. | *Prognosis of colon polyps is generally excellent.<ref name="HuangFarraye2010">{{cite journal|last1=Huang|first1=Christopher S|last2=Farraye|first2=Francis A|last3=Yang|first3=Shi|last4=O'Brien|first4=Michael J|title=The Clinical Significance of Serrated Polyps|journal=The American Journal of Gastroenterology|volume=106|issue=2|year=2010|pages=229–240|issn=0002-9270|doi=10.1038/ajg.2010.429}}</ref> | ||
*The presence of multiple polyps is associated with genetic disorders with a particularly poor prognosis. | *The presence of multiple polyps is associated with genetic disorders with a particularly poor prognosis. | ||
*Colon polyps that are associated with BRAF and KRAS mutations have a poor prognosis.<ref name="BettingtonWalker2013">{{cite journal|last1=Bettington|first1=Mark|last2=Walker|first2=Neal|last3=Clouston|first3=Andrew|last4=Brown|first4=Ian|last5=Leggett|first5=Barbara|last6=Whitehall|first6=Vicki|title=The serrated pathway to colorectal carcinoma: current concepts and challenges|journal=Histopathology|volume=62|issue=3|year=2013|pages=367–386|issn=03090167|doi=10.1111/his.12055}}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} |
Revision as of 05:27, 22 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- Colon polyps are very common in general population.[1]
- They are usually found during screening colonoscopy.[2]
- Polyps might grow and cause symptoms including obstruction, bleeding, and changes in bowel habits.
- Some of them might have malignant potential.
- If left untreated, it may progress to develop colorectal cancer.
- All polyps are recommended to be resected.
Complications
Prognosis
- Prognosis of colon polyps is generally excellent.[1]
- The presence of multiple polyps is associated with genetic disorders with a particularly poor prognosis.
- Colon polyps that are associated with BRAF and KRAS mutations have a poor prognosis.[4]
References
- ↑ 1.0 1.1 Huang, Christopher S; Farraye, Francis A; Yang, Shi; O'Brien, Michael J (2010). "The Clinical Significance of Serrated Polyps". The American Journal of Gastroenterology. 106 (2): 229–240. doi:10.1038/ajg.2010.429. ISSN 0002-9270.
- ↑ 2.0 2.1 Bonnington, Stewart N (2016). "Surveillance of colonic polyps: Are we getting it right?". World Journal of Gastroenterology. 22 (6): 1925. doi:10.3748/wjg.v22.i6.1925. ISSN 1007-9327.
- ↑ Shussman, N.; Wexner, S. D. (2014). "Colorectal polyps and polyposis syndromes". Gastroenterology Report. 2 (1): 1–15. doi:10.1093/gastro/got041. ISSN 2052-0034.
- ↑ Bettington, Mark; Walker, Neal; Clouston, Andrew; Brown, Ian; Leggett, Barbara; Whitehall, Vicki (2013). "The serrated pathway to colorectal carcinoma: current concepts and challenges". Histopathology. 62 (3): 367–386. doi:10.1111/his.12055. ISSN 0309-0167.