Multiple sclerosis causes: Difference between revisions
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==== Autoimmunity: ==== | ==== Autoimmunity: ==== | ||
The main [[hypothesis]] regarding [[MS]] [[etiology]] is that it is caused by an [[autoimmune reaction]] against [[central nervous system]] ([[CNS]]). Self reactive [[T cell|T cells]] which has been activated by a foreign ([[virus]] for example) or native factor, will attack the [[myelin sheath]] around the [[neurons]]. Presents of autoreactive [[T cell|T cells]] and myelin basic protein-specific [[CD4+ T cells]] in the [[peripheral blood smear]] of [[MS]] [[Patient|patients]] supports the [[Autoimmunity|autoimmune]] [[hypothesis]]. | The main [[hypothesis]] regarding [[MS]] [[etiology]] is that it is caused by an [[autoimmune reaction]] against [[central nervous system]] ([[CNS]]). Self reactive [[T cell|T cells]] which has been activated by a foreign ([[virus]] for example) or native factor, will attack the [[myelin sheath]] around the [[neurons]]. <ref name="pmid19300953">{{cite journal |vauthors=Korn T |title=Pathophysiology of multiple sclerosis |journal=J. Neurol. |volume=255 Suppl 6 |issue= |pages=2–6 |year=2008 |pmid=19300953 |doi=10.1007/s00415-008-6001-2 |url=}}</ref> Presents of autoreactive [[T cell|T cells]] and myelin basic protein-specific [[CD4+ T cells]] in the [[peripheral blood smear]] of [[MS]] [[Patient|patients]] supports the [[Autoimmunity|autoimmune]] [[hypothesis]]. | ||
==== Genetic: ==== | ==== Genetic: ==== | ||
Revision as of 18:18, 23 January 2018
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Overview
Causes
Multiple sclerosis may be caused by:
Autoimmunity:
The main hypothesis regarding MS etiology is that it is caused by an autoimmune reaction against central nervous system (CNS). Self reactive T cells which has been activated by a foreign (virus for example) or native factor, will attack the myelin sheath around the neurons. [1] Presents of autoreactive T cells and myelin basic protein-specific CD4+ T cells in the peripheral blood smear of MS patients supports the autoimmune hypothesis.
Genetic:
Infectious:
Degenerative:
References
- ↑ Korn T (2008). "Pathophysiology of multiple sclerosis". J. Neurol. 255 Suppl 6: 2–6. doi:10.1007/s00415-008-6001-2. PMID 19300953.