Cholangiocarcinoma classification: Difference between revisions

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***Lymphoepithelial type
***Lymphoepithelial type
***Others
***Others
'''Intrahepatic Bile Duct Cancer'''
*Mass-forming tumor growth pattern
*Periductal-infiltrating tumor growth pattern
*Mixed mass-forming and periductal-infiltrating growth pattern




'''Extrahepatic Bile Duct Cancer'''
'''Perihilar Bile Duct Cancer'''
*Carcinoma in situ
*Carcinoma in situ
*Adenocarcinoma, not otherwise specified (NOS)
*Adenocarcinoma, not otherwise specified (NOS)
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*Papillary carcinoma
*Papillary carcinoma
:*Noninvasive
:*Noninvasive
*Papillary carcinoma
:*Invasive
*:Invasive
*Carcinoma, NOS
*Carcinoma, NOS


'''Perihilar Bile Duct Cancer'''
'''Extrahepatic Bile Duct Cancer'''
*Carcinoma in situ
*Carcinoma in situ
*Adenocarcinoma, not otherwise specified (NOS)
*Adenocarcinoma, not otherwise specified (NOS)
Line 67: Line 71:
*Papillary carcinoma
*Papillary carcinoma
:*Noninvasive
:*Noninvasive
:*Invasive
*Papillary carcinoma
*:Invasive
*Carcinoma, NOS
*Carcinoma, NOS
'''Intrahepatic Bile Duct Cancer'''
*Mass-forming tumor growth pattern
*Periductal-infiltrating tumor growth pattern
*Mixed mass-forming and periductal-infiltrating growth pattern


*Perihilar cholangiocarcinoma may be classified according to Bismuth-Corlette classification into five subtypes based on the extent of ductal infiltration:
*Perihilar cholangiocarcinoma may be classified according to Bismuth-Corlette classification into five subtypes based on the extent of ductal infiltration:

Revision as of 20:58, 24 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Classification

  • Cholangiocarcinoma may be classified according to location of the tumor into three groups:[1]
    • Intrahepatic bile duct cancer
    • Perihilar bile duct cancer
    • Extrahepatic bile duct cancer
  • Intrahepatic cholangiocarcinoma may be classified according to gross and histological features into four subtypes:[2]
    • Conventional type (bile duct type type)
      • Small bile duct type (peripheral type)
      • Large bile duct type (perihilar type)
    • Bile ductular type
    • Intraductal type
      • Papillary type
      • Tubular type
      • Superficial spreading type
    • Rare variants
      • Squamous/adenosquamous cell type
      • Mucinous/signet ring cell
      • Clear cell type
      • Undifferentiated type
      • Lymphoepithelial type
      • Others

Intrahepatic Bile Duct Cancer

  • Mass-forming tumor growth pattern
  • Periductal-infiltrating tumor growth pattern
  • Mixed mass-forming and periductal-infiltrating growth pattern


Perihilar Bile Duct Cancer

  • Carcinoma in situ
  • Adenocarcinoma, not otherwise specified (NOS)
  • Adenocarcinoma
  • Intestinal type
  • Mucinous type
  • Clear cell type
  • Signet-ring cell carcinoma
  • Adenosquamous carcinoma
  • Squamous cell carcinoma
  • Small cell (oat cell) carcinoma
  • Undifferentiated carcinoma
  • Spindle cell type
  • Giant cell type
  • Small cell type
  • Papillomatosis
  • Papillary carcinoma
  • Noninvasive
  • Invasive
  • Carcinoma, NOS

Extrahepatic Bile Duct Cancer

  • Carcinoma in situ
  • Adenocarcinoma, not otherwise specified (NOS)
  • Adenocarcinoma
  • Intestinal type
  • Mucinous type
  • Clear cell type
  • Signet-ring cell carcinoma
  • Adenosquamous carcinoma
  • Squamous cell carcinoma
  • Small cell (oat cell) carcinoma
  • Undifferentiated carcinoma
  • Spindle cell type
  • Giant cell type
  • Small cell type
  • Papillomatosis
  • Papillary carcinoma
  • Noninvasive
  • Papillary carcinoma
    Invasive
  • Carcinoma, NOS
  • Perihilar cholangiocarcinoma may be classified according to Bismuth-Corlette classification into five subtypes based on the extent of ductal infiltration:
    • Type I: Limited to the common hepatic duct, below the level of the confluence of the right and left hepatic ducts
    • Type II: Involves the confluence of the right and left hepatic ducts
    • Type IIIa: Type II and extends to the bifurcation of the right hepatic duct
    • Type IIIb: Type II and extends to the bifurcation of the left hepatic duct
    • Type IV: Extending to the bifurcations of both right and left hepatic duct or multifocal involvement
    • Type V: Stricture at the junction of common bile duct and cystic duct

References

  1. DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD (2007). "Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution". Ann. Surg. 245 (5): 755–62. doi:10.1097/01.sla.0000251366.62632.d3. PMC 1877058. PMID 17457168.
  2. Nakanuma Y, Sato Y, Harada K, Sasaki M, Xu J, Ikeda H (2010). "Pathological classification of intrahepatic cholangiocarcinoma based on a new concept". World J Hepatol. 2 (12): 419–27. doi:10.4254/wjh.v2.i12.419. PMC 3010511. PMID 21191517.