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==Classification==
==Classification==
*Cholangiocarcinoma may be classified according to location of the tumor into three groups:<ref name="pmid17457168">{{cite journal |vauthors=DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD |title=Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution |journal=Ann. Surg. |volume=245 |issue=5 |pages=755–62 |year=2007 |pmid=17457168 |pmc=1877058 |doi=10.1097/01.sla.0000251366.62632.d3 |url=}}</ref>
*Cholangiocarcinoma may be classified according to location of the tumor into three subtypes:<ref name="pmid17457168">{{cite journal |vauthors=DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD |title=Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution |journal=Ann. Surg. |volume=245 |issue=5 |pages=755–62 |year=2007 |pmid=17457168 |pmc=1877058 |doi=10.1097/01.sla.0000251366.62632.d3 |url=}}</ref>
**Intrahepatic bile duct cancer
**Intrahepatic bile duct cancer
**Perihilar bile duct cancer
**Perihilar bile duct cancer
**Extrahepatic bile duct cancer
**Extrahepatic bile duct cancer
===Cellular Classification of Cholangiocarcinoma===
'''Extrahepatic Bile Duct Cancer'''
*Carcinoma in situ
*Adenocarcinoma, not otherwise specified (NOS)
*Adenocarcinoma
:*Intestinal type
:*Mucinous type
:*Clear cell type
*Signet-ring cell carcinoma
*Adenosquamous carcinoma
*Squamous cell carcinoma
*Small cell (oat cell) carcinoma
*Undifferentiated carcinoma
:*Spindle cell type
:*Giant cell type
:*Small cell type
*Papillomatosis
*Papillary carcinoma
:*Noninvasive
*Papillary carcinoma
*:Invasive
*Carcinoma, NOS


'''Gross and histological features'''
'''Perihilar Bile Duct Cancer'''
*Intrahepatic cholangiocarcinoma may be classified according to gross and histological features into four subtypes:<ref name="pmid21191517">{{cite journal |vauthors=Nakanuma Y, Sato Y, Harada K, Sasaki M, Xu J, Ikeda H |title=Pathological classification of intrahepatic cholangiocarcinoma based on a new concept |journal=World J Hepatol |volume=2 |issue=12 |pages=419–27 |year=2010 |pmid=21191517 |pmc=3010511 |doi=10.4254/wjh.v2.i12.419 |url=}}</ref>
*Carcinoma in situ
**'''Conventional type (bile duct type type)'''
*Adenocarcinoma, not otherwise specified (NOS)
***Small bile duct type (peripheral type)
*Adenocarcinoma
***Large bile duct type (perihilar type)
:*Intestinal type
**'''Bile ductular type'''
:*Mucinous type
**'''Intraductal type'''
:*Clear cell type
***Papillary type
*Signet-ring cell carcinoma
***Tubular type
*Adenosquamous carcinoma
***Superficial spreading type
*Squamous cell carcinoma
**'''Rare variants'''
*Small cell (oat cell) carcinoma
***Squamous/adenosquamous cell type
*Undifferentiated carcinoma
***Mucinous/signet ring cell
:*Spindle cell type
***Clear cell type
:*Giant cell type
***Undifferentiated type
:*Small cell type
***Lymphoepithelial type
*Papillomatosis
***Others
*Papillary carcinoma
 
:*Noninvasive
'''Cellular classification'''
:*Invasive
*Intrahepatic cholangiocarcinoma may be classified according to cellular features into four subtypes:
**Intrahepatic Bile Duct Cancer
***Mass-forming tumor growth pattern
***Periductal-infiltrating tumor growth pattern
***Mixed mass-forming and periductal-infiltrating growth pattern
*Perihilar Bile Duct Cancer
**Carcinoma in situ
**Adenocarcinoma, not otherwise specified (NOS)
**Adenocarcinoma
***Intestinal type
***Mucinous type
***Clear cell type
***Signet-ring cell carcinoma
***Adenosquamous carcinoma
***Squamous cell carcinoma
***Small cell (oat cell) carcinoma
***Undifferentiated carcinoma
***Spindle cell type
***Small cell type
***Papillomatosis
***Papillary carcinoma
****Noninvasive
****Invasive
***Carcinoma, NOS
 
*Extrahepatic Bile Duct Cancer
**Carcinoma in situ
**Adenocarcinoma, not otherwise specified (NOS)
**Adenocarcinoma
**Intestinal type
**Mucinous type
***Clear cell type
**Signet-ring cell carcinoma
**Adenosquamous carcinoma
**Squamous cell carcinoma
**Small cell (oat cell) carcinoma
**Undifferentiated carcinoma
***Spindle cell type
***Giant cell type
***Small cell type
**Papillomatosis
**Papillary carcinoma
***Noninvasive
**Papillary carcinoma
***Invasive
*Carcinoma, NOS
*Carcinoma, NOS


'''Bismuth-Corlette classification'''
'''Intrahepatic Bile Duct Cancer'''
*Perihilar cholangiocarcinoma may be classified according to Bismuth-Corlette classification into five subtypes based on the extent of ductal infiltration:
*Mass-forming tumor growth pattern
**'''Type I:'''  Limited to the common hepatic duct, below the level of the confluence of the right and left hepatic ducts
*Periductal-infiltrating tumor growth pattern
**'''Type II:'''  Involves the confluence of the right and left hepatic ducts
*Mixed mass-forming and periductal-infiltrating growth pattern
**'''Type IIIa:'''  Type II and extends to the bifurcation of the right hepatic duct
**'''Type IIIb:'''  Type II and extends to the bifurcation of the left hepatic duct
**'''Type IV:''' Extending to the bifurcations of both right and left hepatic duct or multifocal involvement
**'''Type V:'''  Stricture at the junction of common bile duct and cystic duct


==References==
==References==

Revision as of 03:37, 26 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Classification

  • Cholangiocarcinoma may be classified according to location of the tumor into three subtypes:[1]
    • Intrahepatic bile duct cancer
    • Perihilar bile duct cancer
    • Extrahepatic bile duct cancer

Cellular Classification of Cholangiocarcinoma

Extrahepatic Bile Duct Cancer

  • Carcinoma in situ
  • Adenocarcinoma, not otherwise specified (NOS)
  • Adenocarcinoma
  • Intestinal type
  • Mucinous type
  • Clear cell type
  • Signet-ring cell carcinoma
  • Adenosquamous carcinoma
  • Squamous cell carcinoma
  • Small cell (oat cell) carcinoma
  • Undifferentiated carcinoma
  • Spindle cell type
  • Giant cell type
  • Small cell type
  • Papillomatosis
  • Papillary carcinoma
  • Noninvasive
  • Papillary carcinoma
    Invasive
  • Carcinoma, NOS

Perihilar Bile Duct Cancer

  • Carcinoma in situ
  • Adenocarcinoma, not otherwise specified (NOS)
  • Adenocarcinoma
  • Intestinal type
  • Mucinous type
  • Clear cell type
  • Signet-ring cell carcinoma
  • Adenosquamous carcinoma
  • Squamous cell carcinoma
  • Small cell (oat cell) carcinoma
  • Undifferentiated carcinoma
  • Spindle cell type
  • Giant cell type
  • Small cell type
  • Papillomatosis
  • Papillary carcinoma
  • Noninvasive
  • Invasive
  • Carcinoma, NOS

Intrahepatic Bile Duct Cancer

  • Mass-forming tumor growth pattern
  • Periductal-infiltrating tumor growth pattern
  • Mixed mass-forming and periductal-infiltrating growth pattern

References

  1. ↑ DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD (2007). "Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution". Ann. Surg. 245 (5): 755–62. doi:10.1097/01.sla.0000251366.62632.d3. PMC 1877058. PMID 17457168.
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