Sinusoidal obstruction syndrome classification

Sinusoidal obstruction syndrome Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There is no established system for the classification of sinusoidal obstruction syndrome.

Classification

There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and sever.

LAB	FORMULA/ VARIABLE	NORMAL VALUE	VALUE IN HHS
Plasma glucose (mg/dL)	Direct measurement	< 200 mg/dl	> 600 mg/dl
Arterial pH	Blood pH	7.35-7.45	> 7.30
Anion gap	(Na+) – (Cl– + HCO3–)	7 to 13 (mEq/L)	Variable
Serum osmolality	2(Na + K) + (glucose/18) + (blood urea nitrogen/2.8)	285 to 295 mOsm/kg (285 to 295 mmol/kg) of water	Increased (> 320mOsm/kg)
Plasma ketones	Direct measurement	Negative	Trace or negative
Urine ketones	Direct measurement	Negative	Trace or negative
Serum bicarbonate	Direct measurement	23 - 29 mEq/L	> 18 mEq/L
Blood urea nitrogen (BUN), creatinine levels	N/A	BUN: 7-20 mg/dl Creatinine levels: 0.8-1.2mg/dl	Increased (Dehydration and decreased renal perfusion)