Cholangiocarcinoma medical therapy: Difference between revisions
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===Photodynamic Therapy=== | ===Photodynamic Therapy=== | ||
[[Photodynamic therapy]] | *[[Photodynamic therapy]] | ||
**Injected with a light-sensitizing agent and light is then applied [[endoscopy|endoscopically]] directly to the tumor<ref>{{cite journal |author=Ortner M, Caca K, Berr F, Liebetruth J, Mansmann U, Huster D, Voderholzer W, Schachschal G, Mössner J, Lochs H |title=Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study |journal=Gastroenterology |volume=125 |issue=5 |pages=1355–63 |year=2003 |pmid=14598251}}</ref><ref>{{cite journal |author=Zoepf T, Jakobs R, Arnold J, Apel D, Riemann J |title=Palliation of nonresectable bile duct cancer: improved survival after photodynamic therapy |journal=Am J Gastroenterol |volume=100 |issue=11 |pages=2426–30 |year=2005 |pmid=16279895}}</ref> | |||
==References== | ==References== | ||
Revision as of 15:57, 30 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Chemotherapy is indicated for unresectable cholangiocarcinoma as palliative chemotherapy. Chemotherapy agents used to treat cholangiocarcinoma include 5-fluorouracil, gemcitabine, irinotecan, cisplatin, or doxorubicin.
Medical Therapy
The majority of cases of cholangiocarcinoma present as unresectable disease.[1] If the tumor cannot be surgically removed, patients are often treated with palliative chemotherapy with or without radiotherapy.
Chemotherapy
- 1.Chemotherapy
- Preferred regimen (1): 5-fluorouracil 600 mg/m2 with leucovorin 400 mg/m2 over 2 hours once every 2 weeks
- Alternative regimen (2): Gemcitabine 1,000 mg/m2 plus cisplatin
- Alternative regimen (3): Irinotecan 125 mg/m2 q14 days
- Alternative regimen (4): Oxaliplatin 400 mg/m2
- Alternative regimen (5): Doxorubicin 60-75 mg/m2 q21 days
- Alternative regimen (6): Capecitabine 650 mg/m2 q21 days for 2 weeks
- Alternative regimen (7): Erlotinib PO 100 mg/day
Regional therapies
- Regional therapies is recommended among patients with small cholangiocarcinomas, when the general health condition of the patient does not allow a more aggressive treatment:
- Transarterial chemoembolization (TACE)
- Radioembolization
Photodynamic Therapy
- Photodynamic therapy
- Injected with a light-sensitizing agent and light is then applied endoscopically directly to the tumor[2][3]
References
- ↑ Vauthey J, Blumgart L (1994). "Recent advances in the management of cholangiocarcinomas". Semin. Liver Dis. 14 (2): 109–14. PMID 8047893.
- ↑ Ortner M, Caca K, Berr F, Liebetruth J, Mansmann U, Huster D, Voderholzer W, Schachschal G, Mössner J, Lochs H (2003). "Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study". Gastroenterology. 125 (5): 1355–63. PMID 14598251.
- ↑ Zoepf T, Jakobs R, Arnold J, Apel D, Riemann J (2005). "Palliation of nonresectable bile duct cancer: improved survival after photodynamic therapy". Am J Gastroenterol. 100 (11): 2426–30. PMID 16279895.