Sinusoidal obstruction syndrome pathophysiology: Difference between revisions
Jump to navigation
Jump to search
| Line 27: | Line 27: | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
The most important histopathological characteristics of sinusoidal obstruction syndrome are:<ref name="pmid6363247">{{cite journal |vauthors=McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED |title=Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors |journal=Hepatology |volume=4 |issue=1 |pages=116–22 |year=1984 |pmid=6363247 |doi= |url=}}</ref><ref name="pmid2438942">{{cite journal |vauthors=Shulman HM, Gown AM, Nugent DJ |title=Hepatic veno-occlusive disease after bone marrow transplantation. Immunohistochemical identification of the material within occluded central venules |journal=Am. J. Pathol. |volume=127 |issue=3 |pages=549–58 |year=1987 |pmid=2438942 |pmc=1899766 |doi= |url=}}</ref><ref name="pmid8175139">{{cite journal |vauthors=Shulman HM, Fisher LB, Schoch HG, Henne KW, McDonald GB |title=Veno-occlusive disease of the liver after marrow transplantation: histological correlates of clinical signs and symptoms |journal=Hepatology |volume=19 |issue=5 |pages=1171–81 |year=1994 |pmid=8175139 |doi= |url=}}</ref> | |||
*Sinusoidal dilation | *Sinusoidal dilation | ||
*Portal tract changes of fibrosis and bile ductular reaction | *Portal tract changes of fibrosis and bile ductular reaction | ||
Revision as of 20:44, 1 February 2018
|
Sinusoidal obstruction syndrome Microchapters |
|
Differentiating Sinusoidal obstruction syndrome from Other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Sinusoidal obstruction syndrome pathophysiology On the Web |
|
American Roentgen Ray Society Images of Sinusoidal obstruction syndrome pathophysiology |
|
Directions to Hospitals Treating Sinusoidal obstruction syndrome |
|
Risk calculators and risk factors for Sinusoidal obstruction syndrome pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Pathogenesis
- Sinusoidal obstruction syndrome (SOS) occurs due to obstruction of the hepatic venules and sinusoids rather than hepatic vein or inferior vena cava as seen in Budd Chiari syndrome.
- Hepatic sinusoidal obstruction syndrome (SOS) is mainly seen in hematopoietic cell transplantation.
- The development of sinusoidal obstruction syndrome (SOS) begins with the injury to the hepatic venous endothelium. It is thought that preexisting liver disease increases the risk of developing sinusoidal obstruction syndrome (SOS) due to impairment of drug metabolism which predisposes to the endothelial injury.
- The endothelial cells in patients with hepatitis may have abnormal expression of adhesion molecules and procoagulant factors.
- The deposition of fibrinogen and factor VIII within the sinusoids leads to their dilation and congestion by erythrocytes. The progressive occlusion of venules leads to widespread zonal liver disruption and centrilobular hemorrhagic necrosis.
- The later changes in sinusoids include deposition of collagen, sclerosis of venular walls, fibrosis of the lumens and ultimately occlusion of hepatic venules.
- The severity of symptoms depends on the number of sinusoids involve and severity of the histologic changes.
Gross Pathology
Template Sentences
- Template Sentences 1: On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
- Template Sentence 2: The most important characteristics of [disease name] on gross pathology are:
- Organ 1: List of characteristics + image
- Organ 2: List of characteristics + image
- Organ 3: List of characteristics + image
- This section is a good place to include pictures. Search for copyleft images on The Pathology Wiki [2] and Ask Dr. Wiki [3].
- For an example of this section, click here.
Microscopic Pathology
The most important histopathological characteristics of sinusoidal obstruction syndrome are:[1][2][3]
- Sinusoidal dilation
- Portal tract changes of fibrosis and bile ductular reaction
- Sclerosis of venular walls
- Sinusoidal endothelial cell detachment from the space of Disse can be seen on electron microscopy
References
- ↑ McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED (1984). "Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors". Hepatology. 4 (1): 116–22. PMID 6363247.
- ↑ Shulman HM, Gown AM, Nugent DJ (1987). "Hepatic veno-occlusive disease after bone marrow transplantation. Immunohistochemical identification of the material within occluded central venules". Am. J. Pathol. 127 (3): 549–58. PMC 1899766. PMID 2438942.
- ↑ Shulman HM, Fisher LB, Schoch HG, Henne KW, McDonald GB (1994). "Veno-occlusive disease of the liver after marrow transplantation: histological correlates of clinical signs and symptoms". Hepatology. 19 (5): 1171–81. PMID 8175139.