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==Overview==
==Overview==
The symptoms of functional dyspepsia are directly caused by two major [[Pathophysiology|pathophysiological]] abnormalities in [[Abnormality (behavior)|abnormal]] [[Gastric motility disorder|gastric motility]] and [[visceral]] [[hypersensitivity]]. These [[Mechanism of action|mechanisms]] occur in patients who have acquired excessive responsiveness to stress as a result of the environment during early life, [[genetic]] abnormalities, [[residual]] [[inflammation]] after [[gastrointestinal]] [[Infection|infections]], or other causes, with the process modified by factors including psychophysiological abnormalities, [[abnormal]] secretion of [[gastric acid]], [[Helicobacter pylori infection]], diet, and lifestyle.
The [[symptoms]] of functional dyspepsia are directly caused by two major [[Pathophysiology|pathophysiological]] abnormalities in [[Gastric motility disorder|gastric motility]] and [[visceral]] sensitivity. These [[Mechanism of action|mechanisms]] occur in patients who have acquired excessive responsiveness to stress as a result of the environment during early life, [[genetic]] abnormalities, [[residual]] [[inflammation]] after [[gastrointestinal]] [[Infection|infections]], or other causes. The process may be modified by factors including psychophysiological abnormalities, [[abnormal]] secretion of [[gastric acid]], [[Helicobacter pylori infection]], diet, and lifestyle.


==Pathophysiology==
==Pathophysiology==

Revision as of 01:52, 12 February 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ajay Gade MD[2]]

Overview

The symptoms of functional dyspepsia are directly caused by two major pathophysiological abnormalities in gastric motility and visceral sensitivity. These mechanisms occur in patients who have acquired excessive responsiveness to stress as a result of the environment during early life, genetic abnormalities, residual inflammation after gastrointestinal infections, or other causes. The process may be modified by factors including psychophysiological abnormalities, abnormal secretion of gastric acid, Helicobacter pylori infection, diet, and lifestyle.

Pathophysiology

The pathophysiology of dyspepsia is as follows:[1][2][3][4][5][6][7]

Physiology of Digestion

Pathophysiology of Functional Dyspepsia

References

  1. Talley NJ, Ford AC (2015). "Functional Dyspepsia". N. Engl. J. Med. 373 (19): 1853–63. doi:10.1056/NEJMra1501505. PMID 26535514.
  2. Napthali K, Koloski N, Walker MM, Talley NJ (2016). "Women and functional dyspepsia". Womens Health (Lond). 12 (2): 241–50. doi:10.2217/whe.15.88. PMC 5375052. PMID 26901578.
  3. Talley NJ (2016). "Functional dyspepsia: new insights into pathogenesis and therapy". Korean J. Intern. Med. 31 (3): 444–56. doi:10.3904/kjim.2016.091. PMC 4855108. PMID 27048251.
  4. Ganesh M, Nurko S (2014). "Functional dyspepsia in children". Pediatr Ann. 43 (4): e101–5. doi:10.3928/00904481-20140325-12. PMID 24716560.
  5. Fock KM (2011). "Functional dyspepsia, H. pylori and post infectious FD". J. Gastroenterol. Hepatol. 26 Suppl 3: 39–41. doi:10.1111/j.1440-1746.2011.06649.x. PMID 21443707.
  6. Oustamanolakis P, Tack J (2012). "Dyspepsia: organic versus functional". J. Clin. Gastroenterol. 46 (3): 175–90. doi:10.1097/MCG.0b013e318241b335. PMID 22327302.
  7. Kindt S, Dubois D, Van Oudenhove L, Caenepeel P, Arts J, Bisschops R, Tack J (2009). "Relationship between symptom pattern, assessed by the PAGI-SYM questionnaire, and gastric sensorimotor dysfunction in functional dyspepsia". Neurogastroenterol. Motil. 21 (11): 1183–e105. doi:10.1111/j.1365-2982.2009.01374.x. PMID 19663903.
  8. Miwa H (2012). "Why dyspepsia can occur without organic disease: pathogenesis and management of functional dyspepsia". J Gastroenterol. doi:10.1007/s00535-012-0625-9. PMID 22766746. Unknown parameter |month= ignored (help)

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