Sinusoidal obstruction syndrome primary prevention: Difference between revisions
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==Primary Prevention== | ==Primary Prevention== | ||
Hepatic sinusoidal obstruction syndrome (SOS) is a complication of allogeneic and autologous hematopoietic cell transplantation (HCT). The measures for the primary prevention of sinusoidal obstruction syndrome include: | Hepatic sinusoidal obstruction syndrome (SOS) is a complication of allogeneic and autologous hematopoietic cell transplantation (HCT). The measures for the primary prevention of sinusoidal obstruction syndrome include:<ref name="pmid24102514">{{cite journal |vauthors=Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN |title=BCSH/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation |journal=Br. J. Haematol. |volume=163 |issue=4 |pages=444–57 |year=2013 |pmid=24102514 |doi=10.1111/bjh.12558 |url=}}</ref><ref name="pmid12200355">{{cite journal |vauthors=Ruutu T, Eriksson B, Remes K, Juvonen E, Volin L, Remberger M, Parkkali T, Hägglund H, Ringdén O |title=Ursodeoxycholic acid for the prevention of hepatic complications in allogeneic stem cell transplantation |journal=Blood |volume=100 |issue=6 |pages=1977–83 |year=2002 |pmid=12200355 |doi=10.1182/blood-2001-12-0159 |url=}}</ref> | ||
* Minimizing risks related to the transplant process such as younger age < 7 years, source of the graft (allogeneic greater than autologous), choice of chemotherapy and use of antimicrobials. | * Minimizing risks related to the transplant process such as younger age < 7 years, source of the graft (allogeneic greater than autologous), choice of chemotherapy and use of antimicrobials. | ||
* The exposure to the hepatotoxic agents should be minimized. This includes alcohol, over-the-counter medications (nonsteroidal anti-inflammatory drugs, overuse of acetaminophen), herbal remedies and prescribed drugs with hepatotoxic side effects. | * The exposure to the hepatotoxic agents should be minimized. This includes alcohol, over-the-counter medications (nonsteroidal anti-inflammatory drugs, overuse of acetaminophen), herbal remedies and prescribed drugs with hepatotoxic side effects. | ||
Revision as of 21:28, 5 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Primary preventive measures of sinusoidal obstruction syndrome include minimizing of risks related to the transplant process such as younger age < 7 years, source of the graft (allogeneic greater than autologous), choice of chemotherapy and use of antimicrobials. The exposure to the hepatotoxic agents should be minimized preexisting liver diseases should be managed. The prophylaxis for graft vs host disease should be considered.
Primary Prevention
Hepatic sinusoidal obstruction syndrome (SOS) is a complication of allogeneic and autologous hematopoietic cell transplantation (HCT). The measures for the primary prevention of sinusoidal obstruction syndrome include:[1][2]
- Minimizing risks related to the transplant process such as younger age < 7 years, source of the graft (allogeneic greater than autologous), choice of chemotherapy and use of antimicrobials.
- The exposure to the hepatotoxic agents should be minimized. This includes alcohol, over-the-counter medications (nonsteroidal anti-inflammatory drugs, overuse of acetaminophen), herbal remedies and prescribed drugs with hepatotoxic side effects.
- Treatment of preexisting liver disease.
- The prophylaxis for graft vs host disease should be considered.
References
- ↑ Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN (2013). "BCSH/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation". Br. J. Haematol. 163 (4): 444–57. doi:10.1111/bjh.12558. PMID 24102514.
- ↑ Ruutu T, Eriksson B, Remes K, Juvonen E, Volin L, Remberger M, Parkkali T, Hägglund H, Ringdén O (2002). "Ursodeoxycholic acid for the prevention of hepatic complications in allogeneic stem cell transplantation". Blood. 100 (6): 1977–83. doi:10.1182/blood-2001-12-0159. PMID 12200355.