Primary biliary cirrhosis surgery: Difference between revisions

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*Decompensated [[cirrhosis]]
*Decompensated [[cirrhosis]]
*Endstage [[liver failure]]
*Endstage [[liver failure]]
*Indications specific to endstage [[liver failure]]:
*Indications specific to endstage [[liver failure]] include:
**Refractory [[ascites]]
**Refractory [[ascites]]
**Recurrent [[spontaneous bacterial peritonitis]]
**Recurrent [[spontaneous bacterial peritonitis]]
Line 17: Line 17:
**[[Hepatorenal syndrome|Hepatorenal syndrome type I]]
**[[Hepatorenal syndrome|Hepatorenal syndrome type I]]
**[[Hepatocellular carcinoma]]
**[[Hepatocellular carcinoma]]
*Indications specific to PBC
*Indications specific to primary biliary cirrhosis include:
**Refractory [[pruritus]]
**Refractory [[pruritus]]
**Chronic [[fatigue]]
**Chronic [[fatigue]]
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== Recurrence ==
== Recurrence ==
*In about 20% of the patients the recurrence of [[Primary biliary cirrhosis|primarybiliary cirrhosis]] occurs between 3 and 7 years after [[Liver transplantation|liver transplantation]].
*The recurrence of [[Primary biliary cirrhosis|primarybiliary cirrhosis]] following [[Liver transplantation|liver transplantation]]:<ref name="pmid14594139">{{cite journal |vauthors=MacQuillan GC, Neuberger J |title=Liver transplantation for primary biliary cirrhosis |journal=Clin Liver Dis |volume=7 |issue=4 |pages=941–56, ix |year=2003 |pmid=14594139 |doi= |url=}}</ref><ref name="pmid21459072">{{cite journal |vauthors=Carbone M, Neuberger J |title=Liver transplantation in PBC and PSC: indications and disease recurrence |journal=Clin Res Hepatol Gastroenterol |volume=35 |issue=6-7 |pages=446–54 |year=2011 |pmid=21459072 |doi=10.1016/j.clinre.2011.02.007 |url=}}</ref><ref name="pmid11084062">{{cite journal |vauthors=Gilroy RK, Lynch SV, Strong RW, Kerlin P, Balderson GA, Stuart KA, Crawford DH |title=Confirmation of the role of the Mayo Risk Score as a predictor of resource utilization after orthotopic liver transplantation for primary biliary cirrhosis |journal=Liver Transpl. |volume=6 |issue=6 |pages=749–52 |year=2000 |pmid=11084062 |doi=10.1053/jlts.2000.9746 |url=}}</ref><ref name="pmid11084062">{{cite journal |vauthors=Gilroy RK, Lynch SV, Strong RW, Kerlin P, Balderson GA, Stuart KA, Crawford DH |title=Confirmation of the role of the Mayo Risk Score as a predictor of resource utilization after orthotopic liver transplantation for primary biliary cirrhosis |journal=Liver Transpl. |volume=6 |issue=6 |pages=749–52 |year=2000 |pmid=11084062 |doi=10.1053/jlts.2000.9746 |url=}}</ref><ref name="pmid8750166">{{cite journal |vauthors=Dubel L, Farges O, Bismuth H, Sebagh M, Homberg JC, Johanet C |title=Kinetics of anti-M2 antibodies after liver transplantation for primary biliary cirrhosis |journal=J. Hepatol. |volume=23 |issue=6 |pages=674–80 |year=1995 |pmid=8750166 |doi= |url=}}</ref><ref name="pmid20526013">{{cite journal |vauthors=Ciesek S, Becker T, Manns MP, Strassburg CP |title=Anti-parietal cell autoantibodies (PCA) in primary biliary cirrhosis: a putative marker for recurrence after orthotopic liver transplantation? |journal=Ann Hepatol |volume=9 |issue=2 |pages=181–5 |year=2010 |pmid=20526013 |doi= |url=}}</ref>
 
**About 20% at 5 years
**About 30% at 10 years
**About 40% at 15 years
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 16:16, 6 February 2018

Primary Biliary Cirrhosis Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2]

Overview

The mainstay of treatment for primary primarybiliary cirrhosis is medical therapy. Surgery is usually reserved for patients with either decompensated cirrhosis and endstage liver failure who do not show any improvement with medical therapy.

Indications

Indications for liver transplantation include:

Surgery

Recurrence

References

  1. Wiesner R, Edwards E, Freeman R, Harper A, Kim R, Kamath P; et al. (2003). "Model for end-stage liver disease (MELD) and allocation of donor livers". Gastroenterology. 124 (1): 91–6. doi:10.1053/gast.2003.50016. PMID 12512033.
  2. MacQuillan GC, Neuberger J (2003). "Liver transplantation for primary biliary cirrhosis". Clin Liver Dis. 7 (4): 941–56, ix. PMID 14594139.
  3. Carbone M, Neuberger J (2011). "Liver transplantation in PBC and PSC: indications and disease recurrence". Clin Res Hepatol Gastroenterol. 35 (6–7): 446–54. doi:10.1016/j.clinre.2011.02.007. PMID 21459072.
  4. 4.0 4.1 Gilroy RK, Lynch SV, Strong RW, Kerlin P, Balderson GA, Stuart KA, Crawford DH (2000). "Confirmation of the role of the Mayo Risk Score as a predictor of resource utilization after orthotopic liver transplantation for primary biliary cirrhosis". Liver Transpl. 6 (6): 749–52. doi:10.1053/jlts.2000.9746. PMID 11084062.
  5. Dubel L, Farges O, Bismuth H, Sebagh M, Homberg JC, Johanet C (1995). "Kinetics of anti-M2 antibodies after liver transplantation for primary biliary cirrhosis". J. Hepatol. 23 (6): 674–80. PMID 8750166.
  6. Ciesek S, Becker T, Manns MP, Strassburg CP (2010). "Anti-parietal cell autoantibodies (PCA) in primary biliary cirrhosis: a putative marker for recurrence after orthotopic liver transplantation?". Ann Hepatol. 9 (2): 181–5. PMID 20526013.

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