Differentiating cholangiocarcinoma from other diseases: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Cholangiocarcinoma}} | {{Cholangiocarcinoma}} | ||
{{CMG}}; {{AE}}{{F.K}} | {{CMG}}; {{AE}}{{F.K}} [mailto:fkahe@bidmc.harvard.edu] | ||
==Overview== | ==Overview== | ||
Revision as of 15:03, 12 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2] [3]
Overview
Cholangiocarcinoma must be differentiated from other diseases that cause jaundice, abdominal pain, weight loss, and fatigue, such as gallbladder cancer, hepatocellular carcinoma, pancreatic cancer, cholecystitis, and choledochitis.
Differentiating cholangiocarcinoma from other diseases
Cholangiocarcinoma must be differentiated from other diseases that cause jaundice, abdominal pain, weight loss, and fever such as Gallbladder cancer, hepatocellular carcinoma, pancreatic cancer, cholecystitis, choledochitis and liver fluke infections.
Abbreviations:
RUQ= Right upper quadrant of the abdomen, LUQ= Left upper quadrant, LLQ= Left lower quadrant, RLQ= Right lower quadrant, LFT= Liver function test, SIRS= Systemic inflammatory response syndrome, ERCP= Endoscopic retrograde cholangiopancreatography, IV= Intravenous, N= Normal, AMA= Anti mitochondrial antibodies, LDH= Lactate dehydrogenase, GI= Gastrointestinal, CXR= Chest X ray, IgA= Immunoglobulin A, IgG= Immunoglobulin G, IgM= Immunoglobulin M, CT= Computed tomography, PMN= Polymorphonuclear cells, ESR= Erythrocyte sedimentation rate, CRP= C-reactive protein, TS= Transferrin saturation, SF= Serum Ferritin, SMA= Superior mesenteric artery, SMV= Superior mesenteric vein, ECG= Electrocardiogram
| Disease | Clinical manifestations | Diagnosis | Comments | |||||||||||||
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| Symptoms | Signs | |||||||||||||||
| Abdominal Pain | Fever | Rigors and chills | Nausea or vomiting | Jaundice | Constipation | Diarrhea | Weight loss | GI bleeding | Hypo-
tension |
Guarding | Rebound Tenderness | Bowel sounds | Lab Findings | Imaging | ||
| Cholangiocarcinoma | RUQ | + | − | + | + | − | − | + | − | − | − | + | Normal |
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| Hepatocellular carcinoma/Metastasis | RUQ | + | − | + | + | + | + | + | + | + | − | + |
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Other symptoms: | |
| Pancreatic carcinoma | MidEpigastric | − | − | + | + | + | − | + | − | − | − | + | Normal |
Skin manifestations may include: | ||
| Focal nodular hyperplasia | Diffuse | ± | − | − | ± | − | − | + | + | − | − | − | Normal |
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| Disease | Abdominal Pain | Fever | Rigors and chills | Nausea or vomiting | Jaundice | Constipation | Diarrhea | Weight loss | GI bleeding | Hypo-
tension |
Guarding | Rebound Tenderness | Bowel sounds | Lab Findings | Imaging | Comments |
| Gallbladder cancer | Midepigastric | − | − | + | + | − | + | + | − | − | − | − | Normal |
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| Liver hemangioma | Intermittent RUQ | − | − | + | + | − | − | − | − | − | − | − | Normal |
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| Liver abscess | RUQ | + | − | + | + | − | − | + | − | − | − | − | Normal |
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| Cirrhosis | RUQ+Bloating | + | − | + | + | − | − | + | − | − | − | − | Normal |
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US
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| Inflammatory lesions | RUQ | ± | − | + | + | − | − | − | − | − | − | − | Normal |
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US
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