Idiopathic pulmonary fibrosis pathophysiology: Difference between revisions
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** Type 4 forms the basement membrane | ** Type 4 forms the basement membrane | ||
** Type 5 forms the interstitial tissue | ** Type 5 forms the interstitial tissue | ||
* Normally, collagen is degraded and produced regularly to preserve the normal lung tissue.<ref name="pmid7150261">{{cite journal| author=Laurent GJ| title=Rates of collagen synthesis in lung, skin and muscle obtained in vivo by a simplified method using [3H]proline. | journal=Biochem J | year= 1982 | volume= 206 | issue= 3 | pages= 535-44 | pmid=7150261 | doi= | pmc=1158621 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7150261 }}</ref> | |||
* Collagen is produced by fibroblasts which also can degrade some of the collagen produced. | |||
* Metalloproteinases produced by fibroblasts, neutrophils, and macrophages have the main role in degrading collagen. | |||
==Genetics== | ==Genetics== | ||
Revision as of 15:15, 14 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Pathophysiology
Normal lung tissue
- Lungs are composed normally of extracellular collagen which allows the lungs to exert their breathing efforts.
- Different collagen types in the lung include the following:[1]
- Type 1 and type 3 compose most of the lung tissue
- Type 2 is the main component of the cartilage of the main bronchi
- Type 4 forms the basement membrane
- Type 5 forms the interstitial tissue
- Normally, collagen is degraded and produced regularly to preserve the normal lung tissue.[2]
- Collagen is produced by fibroblasts which also can degrade some of the collagen produced.
- Metalloproteinases produced by fibroblasts, neutrophils, and macrophages have the main role in degrading collagen.
Genetics
Microscopic pathology
Gross pathology
References
- ↑ van der Rest M, Garrone R (1991). "Collagen family of proteins". FASEB J. 5 (13): 2814–23. PMID 1916105.
- ↑ Laurent GJ (1982). "Rates of collagen synthesis in lung, skin and muscle obtained in vivo by a simplified method using [3H]proline". Biochem J. 206 (3): 535–44. PMC 1158621. PMID 7150261.