Mixed connective tissue disease laboratory tests: Difference between revisions
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*Laboratory findings consistent with the diagnosis of MCTD include:<ref name="pmid16391886">{{cite journal |vauthors=Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K |title=Rheumatoid factor isotypes in mixed connective tissue disease |journal=Clin. Rheumatol. |volume=25 |issue=4 |pages=572–4 |date=July 2006 |pmid=16391886 |doi=10.1007/s10067-005-0185-y |url=}}</ref><ref name="pmid15563821">{{cite journal |vauthors=Ruiz Pombo M, Labrador Horrillo M, Selva O'Callaghan A |title=[Undifferentiated, overlapping and mixed connective tissue diseases] |language=Spanish; Castilian |journal=Med Clin (Barc) |volume=123 |issue=18 |pages=712–7 |date=November 2004 |pmid=15563821 |doi= |url=}}</ref> | *Laboratory findings consistent with the diagnosis of MCTD include:<ref name="pmid16391886">{{cite journal |vauthors=Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K |title=Rheumatoid factor isotypes in mixed connective tissue disease |journal=Clin. Rheumatol. |volume=25 |issue=4 |pages=572–4 |date=July 2006 |pmid=16391886 |doi=10.1007/s10067-005-0185-y |url=}}</ref><ref name="pmid15563821">{{cite journal |vauthors=Ruiz Pombo M, Labrador Horrillo M, Selva O'Callaghan A |title=[Undifferentiated, overlapping and mixed connective tissue diseases] |language=Spanish; Castilian |journal=Med Clin (Barc) |volume=123 |issue=18 |pages=712–7 |date=November 2004 |pmid=15563821 |doi= |url=}}</ref> | ||
**Antibodies against the U1-ribonucleoprotein complex (anti U1RNP) | **Antibodies against the U1-ribonucleoprotein complex (anti U1RNP) | ||
**Rheumatoid factor (RF) | **[[Rheumatoid factor|Rheumatoid factor (RF)]] | ||
**High CRP levels<ref name="pmid9802936">{{cite journal |vauthors=Bakri Hassan A, Rönnelid J, Gunnarsson I, Karlsson G, Berg L, Lundberg I |title=Increased serum levels of immunoglobulins, C-reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease |journal=J. Autoimmun. |volume=11 |issue=5 |pages=503–8 |date=October 1998 |pmid=9802936 |doi=10.1006/jaut.1998.0236 |url=}}</ref> | **High [[C-reactive protein|CRP]] levels<ref name="pmid9802936">{{cite journal |vauthors=Bakri Hassan A, Rönnelid J, Gunnarsson I, Karlsson G, Berg L, Lundberg I |title=Increased serum levels of immunoglobulins, C-reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease |journal=J. Autoimmun. |volume=11 |issue=5 |pages=503–8 |date=October 1998 |pmid=9802936 |doi=10.1006/jaut.1998.0236 |url=}}</ref> | ||
**Hypergammaglobulinemia<ref name="pmid8480140">{{cite journal |vauthors=Hämeenkorpi R, Ruuska P, Forsberg S, Tiilikainen R, Mäkitalo R, Hakala M |title=More evidence of distinctive features of mixed connective tissue disease |journal=Scand. J. Rheumatol. |volume=22 |issue=2 |pages=63–8 |date=1993 |pmid=8480140 |doi= |url=}}</ref> | **[[Hypergammaglobulinemia]]<ref name="pmid8480140">{{cite journal |vauthors=Hämeenkorpi R, Ruuska P, Forsberg S, Tiilikainen R, Mäkitalo R, Hakala M |title=More evidence of distinctive features of mixed connective tissue disease |journal=Scand. J. Rheumatol. |volume=22 |issue=2 |pages=63–8 |date=1993 |pmid=8480140 |doi= |url=}}</ref> | ||
**[[Complete blood count]] may shows:<ref name="pmid24353496">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | **[[Complete blood count]] may shows:<ref name="pmid24353496">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | ||
***Anemia | ***[[Anemia]] | ||
***Leucopenia | ***[[Leukopenia|Leucopenia]] | ||
**Circulating immune complexes | **Circulating [[Immune complex|immune complexes]] | ||
**Hypocomplementemia | **[[Complement deficiency|Hypocomplementemia]] | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 14:42, 12 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Laboratory Findings
- Laboratory findings consistent with the diagnosis of MCTD include:[1][2]
- Antibodies against the U1-ribonucleoprotein complex (anti U1RNP)
- Rheumatoid factor (RF)
- High CRP levels[3]
- Hypergammaglobulinemia[4]
- Complete blood count may shows:[5]
- Circulating immune complexes
- Hypocomplementemia
References
- ↑ Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K (July 2006). "Rheumatoid factor isotypes in mixed connective tissue disease". Clin. Rheumatol. 25 (4): 572–4. doi:10.1007/s10067-005-0185-y. PMID 16391886.
- ↑ Ruiz Pombo M, Labrador Horrillo M, Selva O'Callaghan A (November 2004). "[Undifferentiated, overlapping and mixed connective tissue diseases]". Med Clin (Barc) (in Spanish; Castilian). 123 (18): 712–7. PMID 15563821.
- ↑ Bakri Hassan A, Rönnelid J, Gunnarsson I, Karlsson G, Berg L, Lundberg I (October 1998). "Increased serum levels of immunoglobulins, C-reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease". J. Autoimmun. 11 (5): 503–8. doi:10.1006/jaut.1998.0236. PMID 9802936.
- ↑ Hämeenkorpi R, Ruuska P, Forsberg S, Tiilikainen R, Mäkitalo R, Hakala M (1993). "More evidence of distinctive features of mixed connective tissue disease". Scand. J. Rheumatol. 22 (2): 63–8. PMID 8480140.
- ↑ Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E (October 2013). "Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl". Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.