Buerger's disease natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

If left untreated, 75% of patients with Buerger's disease may have a relapsing and remitting course, whilst 20% may progress and 5% may have a benign course of Buerger's disease. Common complications of [disease name] include amputation, gangrene and loss of circulation beyond the affected hand or foot. Smoking cessation leads to an 8-fold decrease in the risk for amputation. Amputation is common and more severe in patients who continue to use tobacco, which often leads to vascular insufficiency. Buerger's is rarely immediately fatal, but rather a life shortening disease. Prognosis of Buerger's disease varies from person to person, depending on the patient's life-style and the severity of the damaged vessels.

Natural History, Complications, and Prognosis

Natural History

• The symptoms of Buerger disease usually develop in the third to forth decade of life, and start with symptoms such as pallor and ischemia of the extremities.
• If left untreated, approximately 75% of patients with Buerger's disease may have a relapsing and remitting course, whilst 20% may progress and 5% may have a benign course of Buerger's disease.

Complications

• Common complications of Buerger disease include:
  • Amputation
  • Gangrene
  • Loss of circulation beyond the affected hand or foot

Prognosis

• Smoking cessation leads to an 8-fold decrease in the risk for amputation.
• Amputation is common and more severe in patients who continue to use tobacco, which often leads to vascular insufficiency.
• Buerger's disease is rarely immediately fatal, but rather a life shortening disease.
• Prognosis of Buerger's disease varies from person to person, depending on:
  • The patient's life-style
  • The severity of the damaged vessels