Antiphospholipid syndrome primary prevention: Difference between revisions
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==Primary Prevention== | ==Primary Prevention== | ||
The primary prevention of antiphospholipid syndrome is as follows:<ref name="pmid24449256">{{cite journal| author=Nalli C, Andreoli L, Casu C, Tincani A| title=Management of recurrent thrombosis in antiphospholipid syndrome. | journal=Curr Rheumatol Rep | year= 2014 | volume= 16 | issue= 3 | pages= 405 | pmid=24449256 | doi=10.1007/s11926-013-0405-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24449256 }} </ref><ref name="pmid15507275">{{cite journal| author=Erkan D, Lockshin MD| title=How much warfarin is enough in APS related thrombosis? | journal=Thromb Res | year= 2004 | volume= 114 | issue= 5-6 | pages= 435-42 | pmid=15507275 | doi=10.1016/j.thromres.2004.06.010 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15507275 }} </ref><ref name="pmid7885428">{{cite journal| author=Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughes GR| title=The management of thrombosis in the antiphospholipid-antibody syndrome. | journal=N Engl J Med | year= 1995 | volume= 332 | issue= 15 | pages= 993-7 | pmid=7885428 | doi=10.1056/NEJM199504133321504 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7885428 }} </ref> | The primary prevention of antiphospholipid syndrome is as follows:<ref name="pmid24449256">{{cite journal| author=Nalli C, Andreoli L, Casu C, Tincani A| title=Management of recurrent thrombosis in antiphospholipid syndrome. | journal=Curr Rheumatol Rep | year= 2014 | volume= 16 | issue= 3 | pages= 405 | pmid=24449256 | doi=10.1007/s11926-013-0405-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24449256 }} </ref><ref name="pmid15507275">{{cite journal| author=Erkan D, Lockshin MD| title=How much warfarin is enough in APS related thrombosis? | journal=Thromb Res | year= 2004 | volume= 114 | issue= 5-6 | pages= 435-42 | pmid=15507275 | doi=10.1016/j.thromres.2004.06.010 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15507275 }} </ref><ref name="pmid7885428">{{cite journal| author=Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughes GR| title=The management of thrombosis in the antiphospholipid-antibody syndrome. | journal=N Engl J Med | year= 1995 | volume= 332 | issue= 15 | pages= 993-7 | pmid=7885428 | doi=10.1056/NEJM199504133321504 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7885428 }} </ref> | ||
* Anticoagulation in patients with risk factors for arterial and venous thrombosis. | * Anticoagulation with low-dose aspirin or warfarin in patients with risk factors for arterial and venous thrombosis. | ||
* Minimizing the contribution of reversible risk factors for recurrent thrombosis. | * Minimizing the contribution of reversible risk factors for recurrent thrombosis. | ||
* A daily low dose of aspirin for primary thrombosis prevention in asymptomatic individuals with persistent antiphospholipid antibodies. | * A daily low dose of aspirin for primary thrombosis prevention in asymptomatic individuals with persistent antiphospholipid antibodies. | ||
Revision as of 16:17, 12 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Feham Tariq, MD [2]
Overview
Primary Prevention
The primary prevention of antiphospholipid syndrome is as follows:[1][2][3]
- Anticoagulation with low-dose aspirin or warfarin in patients with risk factors for arterial and venous thrombosis.
- Minimizing the contribution of reversible risk factors for recurrent thrombosis.
- A daily low dose of aspirin for primary thrombosis prevention in asymptomatic individuals with persistent antiphospholipid antibodies.
- Use of statins in patients with hyperlipidemia.
| Primary thromboprophylaxis | |
|---|---|
| Patients with systemic lupus erythematosus and lupus anticoagulant and/or persistently positive anticardiolipin | Hydroxychloroquine and consider low-dose aspirin |
| Patients with obstetric antiphospholipid syndrome | Low-dose aspirin or no therapy |
| Asymptomatic carriers of antiphospholipid antibodies | No therapy or low dose aspirin |
| All patients with antiphospholipid antibodies | Strict control of vascular risk factors |
| High-risk situations (surgery, post partum, long-lasting immobilisation) | Adequate thromboprophylaxis |
References
- ↑ Nalli C, Andreoli L, Casu C, Tincani A (2014). "Management of recurrent thrombosis in antiphospholipid syndrome". Curr Rheumatol Rep. 16 (3): 405. doi:10.1007/s11926-013-0405-4. PMID 24449256.
- ↑ Erkan D, Lockshin MD (2004). "How much warfarin is enough in APS related thrombosis?". Thromb Res. 114 (5–6): 435–42. doi:10.1016/j.thromres.2004.06.010. PMID 15507275.
- ↑ Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughes GR (1995). "The management of thrombosis in the antiphospholipid-antibody syndrome". N Engl J Med. 332 (15): 993–7. doi:10.1056/NEJM199504133321504. PMID 7885428.