Multiple sclerosis risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
Common [[risk factors]] in the development of multiple sclerosis are smoking<ref name="pmid14581676" />, [[genetic]]<ref name="pmid3376997" />, [[Ethnic group|ethnic]]<ref name="pmid573402" />, [[infection]]<ref name="pmid15210894" />, low vitamine D<ref name="pmid12907484" /> and stress.<ref name="pmid14739563" /> | Common [[risk factors]] in the development of multiple sclerosis are smoking<ref name="pmid14581676">{{cite journal |vauthors=Riise T, Nortvedt MW, Ascherio A |title=Smoking is a risk factor for multiple sclerosis |journal=Neurology |volume=61 |issue=8 |pages=1122–4 |date=October 2003 |pmid=14581676 |doi= |url=}}</ref>, [[genetic]]<ref name="pmid3376997" />, [[Ethnic group|ethnic]]<ref name="pmid573402">{{cite journal |vauthors=Kurtzke JF, Beebe GW, Norman JE |title=Epidemiology of multiple sclerosis in U.S. veterans: 1. Race, sex, and geographic distribution |journal=Neurology |volume=29 |issue=9 Pt 1 |pages=1228–35 |date=September 1979 |pmid=573402 |doi= |url=}}</ref>, [[infection]]<ref name="pmid15210894">{{cite journal |vauthors=Sundström P, Juto P, Wadell G, Hallmans G, Svenningsson A, Nyström L, Dillner J, Forsgren L |title=An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study |journal=Neurology |volume=62 |issue=12 |pages=2277–82 |date=June 2004 |pmid=15210894 |doi= |url=}}</ref>, low vitamine D<ref name="pmid12907484" /> and stress.<ref name="pmid14739563">{{cite journal |vauthors=Coo H, Aronson KJ |title=A systematic review of several potential non-genetic risk factors for multiple sclerosis |journal=Neuroepidemiology |volume=23 |issue=1-2 |pages=1–12 |year=2004 |pmid=14739563 |doi=10.1159/000073969 |url=}}</ref> | ||
==Risk Factors== | ==Risk Factors== | ||
Common risk factors in the development of multiple sclerosis are | |||
=== Common Risk Factors === | |||
Common risk factors in the development of multiple sclerosis are: | |||
==== Smoking ==== | ==== Smoking ==== | ||
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==== Genetic ==== | ==== Genetic ==== | ||
Studies demonstrate that [[MS]] has a strong genetic base. The first degree family of a [[MS]] patient is at a 10-25 times greater risk than normal population, so genetically susceptible people are more likely to develop [[MS]] disease.<ref name="pmid8800940">{{cite journal |vauthors=Robertson NP, Fraser M, Deans J, Clayton D, Walker N, Compston DA |title=Age-adjusted recurrence risks for relatives of patients with multiple sclerosis |journal=Brain |volume=119 ( Pt 2) |issue= |pages=449–55 |date=April 1996 |pmid=8800940 |doi= |url=}}</ref><ref name="pmid3376997">{{cite journal |vauthors=Sadovnick AD, Baird PA, Ward RH |title=Multiple sclerosis: updated risks for relatives |journal=Am. J. Med. Genet. |volume=29 |issue=3 |pages=533–41 |date=March 1988 |pmid=3376997 |doi=10.1002/ajmg.1320290310 |url=}}</ref> | Studies demonstrate that [[MS]] has a strong genetic base. The first degree family of a [[MS]] patient is at a 10-25 times greater risk than normal population, so genetically susceptible people are more likely to develop [[MS]] disease.<ref name="pmid8800940">{{cite journal |vauthors=Robertson NP, Fraser M, Deans J, Clayton D, Walker N, Compston DA |title=Age-adjusted recurrence risks for relatives of patients with multiple sclerosis |journal=Brain |volume=119 ( Pt 2) |issue= |pages=449–55 |date=April 1996 |pmid=8800940 |doi= |url=}}</ref><ref name="pmid3376997">{{cite journal |vauthors=Sadovnick AD, Baird PA, Ward RH |title=Multiple sclerosis: updated risks for relatives |journal=Am. J. Med. Genet. |volume=29 |issue=3 |pages=533–41 |date=March 1988 |pmid=3376997 |doi=10.1002/ajmg.1320290310 |url=}}</ref> | ||
==== Sex ==== | ==== Sex ==== | ||
Prevalence of [[MS]] disease is higher in female. This can be [[hormone]] related or more susceptibility to environmental risk factors.<ref name="pmid17052660">{{cite journal |vauthors=Orton SM, Herrera BM, Yee IM, Valdar W, Ramagopalan SV, Sadovnick AD, Ebers GC |title=Sex ratio of multiple sclerosis in Canada: a longitudinal study |journal=Lancet Neurol |volume=5 |issue=11 |pages=932–6 |date=November 2006 |pmid=17052660 |doi=10.1016/S1474-4422(06)70581-6 |url=}}</ref><ref name="pmid11526384">{{cite journal |vauthors=Whitacre CC |title=Sex differences in autoimmune disease |journal=Nat. Immunol. |volume=2 |issue=9 |pages=777–80 |date=September 2001 |pmid=11526384 |doi=10.1038/ni0901-777 |url=}}</ref> | Prevalence of [[MS]] disease is higher in female. This can be [[hormone]] related or more susceptibility to environmental risk factors.<ref name="pmid17052660">{{cite journal |vauthors=Orton SM, Herrera BM, Yee IM, Valdar W, Ramagopalan SV, Sadovnick AD, Ebers GC |title=Sex ratio of multiple sclerosis in Canada: a longitudinal study |journal=Lancet Neurol |volume=5 |issue=11 |pages=932–6 |date=November 2006 |pmid=17052660 |doi=10.1016/S1474-4422(06)70581-6 |url=}}</ref><ref name="pmid11526384">{{cite journal |vauthors=Whitacre CC |title=Sex differences in autoimmune disease |journal=Nat. Immunol. |volume=2 |issue=9 |pages=777–80 |date=September 2001 |pmid=11526384 |doi=10.1038/ni0901-777 |url=}}</ref> | ||
==== Vitamin D ==== | ==== Vitamin D ==== | ||
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==== stress ==== | ==== stress ==== | ||
Stressful life events can be a risk factor for [[MS]] disease. In patients who already have [[MS]], stress and anxiety can lead to exacerbation of their disease.<ref name="pmid10371517">{{cite journal |vauthors=Goodin DS, Ebers GC, Johnson KP, Rodriguez M, Sibley WA, Wolinsky JS |title=The relationship of MS to physical trauma and psychological stress: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology |journal=Neurology |volume=52 |issue=9 |pages=1737–45 |date=June 1999 |pmid=10371517 |doi= |url=}}</ref> | Stressful life events can be a risk factor for [[MS]] disease. In patients who already have [[MS]], stress and anxiety can lead to exacerbation of their disease.<ref name="pmid10371517">{{cite journal |vauthors=Goodin DS, Ebers GC, Johnson KP, Rodriguez M, Sibley WA, Wolinsky JS |title=The relationship of MS to physical trauma and psychological stress: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology |journal=Neurology |volume=52 |issue=9 |pages=1737–45 |date=June 1999 |pmid=10371517 |doi= |url=}}</ref> | ||
=== Less Common Risk Factors === | |||
==== Ethnic ==== | |||
[[MS]] prevalence is lower in African Americans, Mexicans, Japanese, Chinese and Filipinos people rather than white men.<ref name="pmid573402" /> | |||
==== Epstein-Barr virus ==== | |||
[[Patient|Patients]] affected with [[Epstein Barr virus|Epstein-Barr virus]] seems to be more susceptible to developing [[MS]]. Studies shows that high titer of [[Epstein Barr virus|EBV]] [[Antibody|antibodies]] is a risk factor for [[MS]] disease.<ref name="pmid15210894" /><ref name="pmid15914750">{{cite journal |vauthors=Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D, Ascherio A |title=Temporal relationship between elevation of epstein-barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis |journal=JAMA |volume=293 |issue=20 |pages=2496–500 |date=May 2005 |pmid=15914750 |doi=10.1001/jama.293.20.2496 |url=}}</ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Irfan Dotani Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.
Overview
Common risk factors in the development of multiple sclerosis are smoking[1], genetic[2], ethnic[3], infection[4], low vitamine D[5] and stress.[6]
Risk Factors
Common Risk Factors
Common risk factors in the development of multiple sclerosis are:
Smoking
Various studies show that smoking, beside cardiovascular diseases and cancer, can be a risk factor of multiple sclerosis.[1][7]
Genetic
Studies demonstrate that MS has a strong genetic base. The first degree family of a MS patient is at a 10-25 times greater risk than normal population, so genetically susceptible people are more likely to develop MS disease.[8][2]
Sex
Prevalence of MS disease is higher in female. This can be hormone related or more susceptibility to environmental risk factors.[9][10]
Vitamin D
Low vitamin D level seems to be a risk factor for developing MS since the prevalence of MS is lower in regions where people take vitamin D supplement or have higher sunlight exposure.[5][11]
stress
Stressful life events can be a risk factor for MS disease. In patients who already have MS, stress and anxiety can lead to exacerbation of their disease.[12]
Less Common Risk Factors
Ethnic
MS prevalence is lower in African Americans, Mexicans, Japanese, Chinese and Filipinos people rather than white men.[3]
Epstein-Barr virus
Patients affected with Epstein-Barr virus seems to be more susceptible to developing MS. Studies shows that high titer of EBV antibodies is a risk factor for MS disease.[4][13]
References
- ↑ 1.0 1.1 Riise T, Nortvedt MW, Ascherio A (October 2003). "Smoking is a risk factor for multiple sclerosis". Neurology. 61 (8): 1122–4. PMID 14581676.
- ↑ 2.0 2.1 Sadovnick AD, Baird PA, Ward RH (March 1988). "Multiple sclerosis: updated risks for relatives". Am. J. Med. Genet. 29 (3): 533–41. doi:10.1002/ajmg.1320290310. PMID 3376997.
- ↑ 3.0 3.1 Kurtzke JF, Beebe GW, Norman JE (September 1979). "Epidemiology of multiple sclerosis in U.S. veterans: 1. Race, sex, and geographic distribution". Neurology. 29 (9 Pt 1): 1228–35. PMID 573402.
- ↑ 4.0 4.1 Sundström P, Juto P, Wadell G, Hallmans G, Svenningsson A, Nyström L, Dillner J, Forsgren L (June 2004). "An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study". Neurology. 62 (12): 2277–82. PMID 15210894.
- ↑ 5.0 5.1 van der Mei IA, Ponsonby AL, Dwyer T, Blizzard L, Simmons R, Taylor BV, Butzkueven H, Kilpatrick T (August 2003). "Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study". BMJ. 327 (7410): 316. doi:10.1136/bmj.327.7410.316. PMC 169645. PMID 12907484.
- ↑ Coo H, Aronson KJ (2004). "A systematic review of several potential non-genetic risk factors for multiple sclerosis". Neuroepidemiology. 23 (1–2): 1–12. doi:10.1159/000073969. PMID 14739563.
- ↑ Hernán MA, Olek MJ, Ascherio A (July 2001). "Cigarette smoking and incidence of multiple sclerosis". Am. J. Epidemiol. 154 (1): 69–74. PMID 11427406.
- ↑ Robertson NP, Fraser M, Deans J, Clayton D, Walker N, Compston DA (April 1996). "Age-adjusted recurrence risks for relatives of patients with multiple sclerosis". Brain. 119 ( Pt 2): 449–55. PMID 8800940.
- ↑ Orton SM, Herrera BM, Yee IM, Valdar W, Ramagopalan SV, Sadovnick AD, Ebers GC (November 2006). "Sex ratio of multiple sclerosis in Canada: a longitudinal study". Lancet Neurol. 5 (11): 932–6. doi:10.1016/S1474-4422(06)70581-6. PMID 17052660.
- ↑ Whitacre CC (September 2001). "Sex differences in autoimmune disease". Nat. Immunol. 2 (9): 777–80. doi:10.1038/ni0901-777. PMID 11526384.
- ↑ Munger KL, Zhang SM, O'Reilly E, Hernán MA, Olek MJ, Willett WC, Ascherio A (January 2004). "Vitamin D intake and incidence of multiple sclerosis". Neurology. 62 (1): 60–5. PMID 14718698.
- ↑ Goodin DS, Ebers GC, Johnson KP, Rodriguez M, Sibley WA, Wolinsky JS (June 1999). "The relationship of MS to physical trauma and psychological stress: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology". Neurology. 52 (9): 1737–45. PMID 10371517.
- ↑ Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D, Ascherio A (May 2005). "Temporal relationship between elevation of epstein-barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis". JAMA. 293 (20): 2496–500. doi:10.1001/jama.293.20.2496. PMID 15914750.