Methemoglobinemia causes: Difference between revisions
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Most common cause include different oxidant drugs, toxins or chemicals | Most common cause include different oxidant drugs, toxins or chemicals | ||
==Causes== | ==Causes== <ref>{{Med Toxicol. 1986 Jul-Aug;1(4):253-60. Drug- and chemical-induced methaemoglobinaemia. Clinical features and management. Hall AH, Kulig KW, Rumack BH.pmid=PMID: 3537620}}</ref> <ref>{{Rev Bras Anestesiol. 2008 Nov-Dec;58(6):651-64. Methemoglobinemia: from diagnosis to treatment. [Article in English, Portuguese] do Nascimento TS1, Pereira RO, de Mello HL, Costa J. pmid=19082413}}</ref> | ||
'''1.''' '''Drug Induced''' | '''1.''' '''Drug Induced''' | ||
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'''3. Solid foods''' (not well cooked vegetables high in nitrates in premature infants and infants younger than 4 months) | '''3. Solid foods''' (not well cooked vegetables high in nitrates in premature infants and infants younger than 4 months) | ||
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==References== | ==References== | ||
Revision as of 23:49, 29 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Congenital (Hereditary) Methemoglobinemia
There are three main congenital conditions that lead to methemoglobinemia:
1. Cytochrome b5 reductase deficiency and pyruvate kinase deficiency
2. G6PD deficiency
3. Presence of abnormal hemoglobin (Hb M)
Acquired or Acute Methemoglobinemia
Most common cause include different oxidant drugs, toxins or chemicals
1. Drug Induced
• Anesthetics like *benzocaine, *lidocaine, *prilocaine
• *Nitric oxide
• *Amilnitrate
• Antimalarial drugs like *Primaquine phosphate (in nicotinamide adenine dinucleotide (NADH) methemoglobin reductase deficient individuals)
• *Rasburicase
• *Dapsone
• *Trimethoprim
• *Sulfonamides
• *Aniline dyes
2. Contaminated well water (in premature infants and infants younger than 4 months)
3. Solid foods (not well cooked vegetables high in nitrates in premature infants and infants younger than 4 months)
- ↑ Template:Med Toxicol. 1986 Jul-Aug;1(4):253-60. Drug- and chemical-induced methaemoglobinaemia. Clinical features and management. Hall AH, Kulig KW, Rumack BH.pmid=PMID: 3537620
- ↑ {{Rev Bras Anestesiol. 2008 Nov-Dec;58(6):651-64. Methemoglobinemia: from diagnosis to treatment. [Article in English, Portuguese] do Nascimento TS1, Pereira RO, de Mello HL, Costa J. pmid=19082413}}