Methemoglobinemia differential diagnosis: Difference between revisions
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Depending on the levels of MetHb in the blood we can observe different symptoms as follows: MetHb of 15% presents with skin and blood color changes. Levels above 15% will result in hypoxia and levels above 70% can lead to death. | Depending on the levels of MetHb in the blood we can observe different symptoms as follows: MetHb of 15% presents with skin and blood color changes. Levels above 15% will result in hypoxia and levels above 70% can lead to death. | ||
There are several conditions that can present similar to methemoglobinemia. Note that the hypoxia in methemogobinemia will be unresponsive to oxygen treatment, in comparison to cardiac and pulmonary | There are several conditions that can present similar to methemoglobinemia. Note that the hypoxia in methemogobinemia will be unresponsive to oxygen treatment, in comparison to cardiac and pulmonary causes of hypoxia. Worth mentioning is also that high doses of antidote treatment for methemogobinemia (Methylene blue) can also cause cyanotic discoloration of the skin, but this does not mean that the treatment is inefficient. <ref>{{Rev Bras Anestesiol. 2008 Nov-Dec;58(6):651-64. Methemoglobinemia: from diagnosis to treatment. [Article in English, Portuguese] do Nascimento TS1, Pereira RO, de Mello HL, Costa J. pmid=19082413}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Template:Aksiniya K. Stevasarova, M.D.
Overview
Depending on the levels of MetHb in the blood we can observe different symptoms as follows: MetHb of 15% presents with skin and blood color changes. Levels above 15% will result in hypoxia and levels above 70% can lead to death.
There are several conditions that can present similar to methemoglobinemia. Note that the hypoxia in methemogobinemia will be unresponsive to oxygen treatment, in comparison to cardiac and pulmonary causes of hypoxia. Worth mentioning is also that high doses of antidote treatment for methemogobinemia (Methylene blue) can also cause cyanotic discoloration of the skin, but this does not mean that the treatment is inefficient. [1]
- ↑ {{Rev Bras Anestesiol. 2008 Nov-Dec;58(6):651-64. Methemoglobinemia: from diagnosis to treatment. [Article in English, Portuguese] do Nascimento TS1, Pereira RO, de Mello HL, Costa J. pmid=19082413}}
Differential Diagnosis
• Heart failure
• Pulmonary embolism
• Polycythemia
• Anemia
• Rasbirucase (Rx Tumor Lysis Syndrome)
• Metabolic Acidosis
• Methylene Blue treatment
• Sulfhemoglobin
• Asthma