Methemoglobinemia causes: Difference between revisions
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Methemoglobinemia induced by lidocaine-prilocaine cream. | Methemoglobinemia induced by lidocaine-prilocaine cream. | ||
Shamriz O, Cohen-Glickman I, Reif S, Shteyer E.pmid=24834764}}</ref> | Shamriz O, Cohen-Glickman I, Reif S, Shteyer E.pmid=24834764}}</ref> | ||
• | • [[Methylene blue]] | ||
• | • [[Nitric oxide]] | ||
• | • [[Amyl Nitrate]] | ||
• [[Nitroglycerin]] | |||
• [[Antimalarial drugs]] like *[[Primaquine phosphate]] (in [[nicotinamide adenine dinucleotide]] ([[NADH]]) methemoglobin reductase deficient individuals) | • [[Antimalarial drugs]] like *[[Primaquine phosphate]] (in [[nicotinamide adenine dinucleotide]] ([[NADH]]) methemoglobin reductase deficient individuals) | ||
• | • [[Rasburicase]] <ref>{{Curr Drug Saf. 2017;12(1):13-18. doi: 10.2174/1574886312666170111151246. | ||
Rasburicase-Induced Methemoglobinemia in a Patient with Glucose-6- Phosphate Dehydrogenase Deficiency. | Rasburicase-Induced Methemoglobinemia in a Patient with Glucose-6- Phosphate Dehydrogenase Deficiency. | ||
Khan M, Paul S, Farooq S, Oo TH, Ramshesh P, Jain N1. pmid=28078984}}</ref> | Khan M, Paul S, Farooq S, Oo TH, Ramshesh P, Jain N1. pmid=28078984}}</ref> | ||
• | • [[Sulfasalazine]] | ||
• | • [[Dapsone]] | ||
• | • [[Trimethoprim]] | ||
• | • [[Sulfonamides]] | ||
• | • [[Aniline dyes]]<ref>{{Case Rep Emerg Med. 2015;2015:208732. doi: 10.1155/2015/208732. Epub 2015 Mar 12. | ||
P-chloroaniline poisoning causing methemoglobinemia: a case report and review of the literature. | P-chloroaniline poisoning causing methemoglobinemia: a case report and review of the literature. | ||
Messmer AS1, Nickel CH1, Bareiss D1. pmid=25861488 PMCID: PMC4377359 }}</ref> | Messmer AS1, Nickel CH1, Bareiss D1. pmid=25861488 PMCID: PMC4377359 }}</ref> | ||
• | • [[Metoclopramide]] | ||
• | • [[Chlorates and Bromates]] | ||
'''2. Contaminated well water''' (in premature infants and infants younger than 4 months) <ref>{{Eur J Emerg Med. 2003 Dec;10(4):326-30. | '''2. Contaminated well water''' (in premature infants and infants younger than 4 months) <ref>{{Eur J Emerg Med. 2003 Dec;10(4):326-30. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Template:Aksiniya K. Stevasarova, M.D.
Overview
Methemoglobinemia may be caused by either congenital or acquired conditions.
Causes
Congenital (Hereditary) Methemoglobinemia
- There are three main congenital conditions that lead to methemoglobinemia:
1. Cytochrome b5 reductase deficiency and pyruvate kinase deficiency
3. Presence of abnormal hemoglobin (Hb M)
Acquired or Acute Methemoglobinemia
- Some of the most common causes leading to methemoglobinemia include different oxidant drugs, toxins and chemicals.[1] [2]
1. Drug Induced
• *Anesthetics[3] like *benzocaine[4], *lidocaine[5], *prilocaine[6]
• Antimalarial drugs like *Primaquine phosphate (in nicotinamide adenine dinucleotide (NADH) methemoglobin reductase deficient individuals)
• Dapsone
2. Contaminated well water (in premature infants and infants younger than 4 months) [9] [10]
3. Solid foods (not well cooked vegetables high in nitrates in premature infants and infants younger than 4 months) [11] [12]
References
- ↑ Template:Med Toxicol. 1986 Jul-Aug;1(4):253-60. Drug- and chemical-induced methaemoglobinaemia. Clinical features and management. Hall AH, Kulig KW, Rumack BH.pmid=PMID: 3537620
- ↑ {{Rev Bras Anestesiol. 2008 Nov-Dec;58(6):651-64. Methemoglobinemia: from diagnosis to treatment. [Article in English, Portuguese] do Nascimento TS1, Pereira RO, de Mello HL, Costa J. pmid=19082413}}
- ↑ {{ J Emerg Med. 2018 Mar 5. pii: S0736-4679(18)30095-7. doi: 10.1016/j.jemermed.2018.01.039. [Epub ahead of print] Local Anesthetic-Induced Methemoglobinemia During Pregnancy: A Case Report and Evaluation of Treatment Options. Faust AC1, Guy E1, Baby N2, Ortegon A3.pmid=29519718}}
- ↑ {{ Ann Pharmacother. 1994 May;28(5):643-9. Benzocaine-induced methemoglobinemia: report of a severe reaction and review of the literature. Rodriguez LF1, Smolik LM, Zbehlik AJ.pmid=8069004 }}
- ↑ {{Drug Saf Case Rep. 2018 Apr 7;5(1):15. doi: 10.1007/s40800-018-0081-4. Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report. Gay HC1,2, Amaral AP3. pmid=PMID: 29627919 }}
- ↑ {{Isr Med Assoc J. 2014 Apr;16(4):250-4. Methemoglobinemia induced by lidocaine-prilocaine cream. Shamriz O, Cohen-Glickman I, Reif S, Shteyer E.pmid=24834764}}
- ↑ {{Curr Drug Saf. 2017;12(1):13-18. doi: 10.2174/1574886312666170111151246. Rasburicase-Induced Methemoglobinemia in a Patient with Glucose-6- Phosphate Dehydrogenase Deficiency. Khan M, Paul S, Farooq S, Oo TH, Ramshesh P, Jain N1. pmid=28078984}}
- ↑ {{Case Rep Emerg Med. 2015;2015:208732. doi: 10.1155/2015/208732. Epub 2015 Mar 12. P-chloroaniline poisoning causing methemoglobinemia: a case report and review of the literature. Messmer AS1, Nickel CH1, Bareiss D1. pmid=25861488 PMCID: PMC4377359 }}
- ↑ {{Eur J Emerg Med. 2003 Dec;10(4):326-30. A severe methaemoglobinemia induced by nitrates: a case report. Brunato F1, Garziera MG, Briguglio E. pmid=14676514 }}
- ↑ [www.epa.gov/dwstandardsregulations]
- ↑ [www.fda.gov/Drugs/DrugSafety/ucm250024.htm]
- ↑ [www.fda.gov/forconsumers/consumerupdates/ucm306062.htm]