Fanconi syndrome causes

Fanconi syndrome Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Fanconi syndrome from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study Of Choice
History and Symptoms
Physical Examination
Laboratory Findings
X Ray
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Fanconi syndrome causes On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Fanconi syndrome causes All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Fanconi syndrome causes
CDC on Fanconi syndrome causes
Fanconi syndrome causes in the news
Blogs on Fanconi syndrome causes
Directions to Hospitals Treating Fanconi syndrome
Risk calculators and risk factors for Fanconi syndrome causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Fanconi syndrome could be the result or complication of various causes affecting the normal function of Proximal convoluted tubule (PCT) ; in a simple and useful classification method, the causes could be classified as:

• Genetic causes
  • Accumulation of a toxic substance (e.g. Cystinosis, Tyrozinemia, Lysinuric Protein Intolerance, Glycogen Storage Diseases, Galactosemia, wilson, fructose intolerance)
  • Energy provision failure (e.g. Mitochondriopathies)
  • Disruption of endocytosis and intra-cellular transport mechanisms (e.g. ARC syndrome, Lowe syndrome and Dent disease).
• Exogenous causes (e.g. Heavy metals exposure, Drugs, Chemotherapy)
• Acquired causes (e.g. Multiple myeloma, Amyloidosis, Paroxysmal nocturnal hemoglobinuria)

Causes

Genetic Causes

• Accumulation of a toxic substance
  • Cystinosis
    • The most common inherited cause of Fanconi syndrome in children
  • Tyrozinemia
  • Lysinuric Protein Intolerance
  • Glycogen Storage Disease type I
  • Galactosemia
  • Wilson
  • Fructose intolerance
  • Fanconi-Bickel syndrome
• Energy provision failure
  • Mitochondriopathies
• Disruption of endocytosis and intra-cellular transport
  • Lowe syndrome
  • NaPi-IIa gene mutation
  • EHHADH gene mutations
  • Dent disease

Exogenous causes

• Drugs
  • Anti viral & Anti-retroviral drugs
    • Adefovir
    • Tenofovir
    • Didanosine
    • Cidofovir
    • Lamivudine
    • Stavudine

• • Antibacterial Drugs
    • Tetracyclines
    • Aminoglycosides

• • Anticonvulsants
    • Valproic acid

• Heavy metals
  • Lead
  • cadmium
  • Mercury
  • Copper
• Chemotherapy

• • Alkylating & Platinating Agents
    • Cisplatin
    • Streptozocin
    • Carboplatin
    • Ifosfamide
    • Oxaplatin

• • Mercaptopurine

Acquired causes

• Nephrotic syndrome
• Multiple myeloma
• Amyloidosis
• Paroxysmal nocturnal hemoglobinuria(PNH)
• Sjögren syndrome
• Renal transplantation
• Acute tubulointerstitial nephritis with uveitis (TINU) syndrome
• Autoimmune interstitial nephritis and membranous nephropathy
• Anorexia nervosa
• Untreated condition of distal renal tubular acidosis

Less Common Causes

Less common causes of Fanconi syndrome mostly found on case reports include:

• Other drugs such as: Fumaric Acid, Ranitidine, Salicylate, Methyl-3-Chromone in high doses and for long periods
• Chronic Alcohol abuse
• Crude Chinese herbal drugs (sometimes called Boui-ougi-tou)
• L-Lysine
• Glue Sniffing
• Autosomal dominant Fanconi syndrome with macrosomia and young onset diabetes mellitus
• Arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome
• Idiopathic Fanconi syndrome

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.

3