Focal segmental glomerulosclerosis history and symptoms: Difference between revisions
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===History=== | ===History=== | ||
Patients with focal segmental glomerulosclerosis may have a positive history of: | Patients with focal segmental glomerulosclerosis may have a positive history of: | ||
* | *Positive family history of FSGN | ||
* | *Heroin abuse | ||
* | *Chronic viral infections such as hepatitis B | ||
*Medications such as bisphosphonates | |||
===Common Symptoms=== | ===Common Symptoms=== | ||
Revision as of 13:58, 11 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
History and Symptoms
The hallmark of focal segmental glomerulosclerosis is nephrotic-range proteinuria.[1]
History
Patients with focal segmental glomerulosclerosis may have a positive history of:
- Positive family history of FSGN
- Heroin abuse
- Chronic viral infections such as hepatitis B
- Medications such as bisphosphonates
Common Symptoms
Common symptoms of focal segmental glomerulosclerosis include:[2]
- Proteinuria
- Hematuria
- Anasarca
- Headache and blurry vision which is suggestive of high blood pressure
Less Common Symptoms
Less common symptoms of [disease name] include
- Fatigue
- Malaise
- [Symptom 2]
- [Symptom 3]
Clinical Presentation
Generally, primary (idiopathic) focal segmental glomerulosclerosis (FSGS) starts abruptly whereas secondary FSGS has a more insidious onset. The hallmark of FSGS is appearing in approximately 70% of patients.[3]
Common signs and symptoms associated with FSGS are shown below[1][3]:
- Other signs of renal insufficiency
Additionally, a must be ruled out during history-taking.
In contrast, patients with secondary FSGS is often present with non-nephrotic range proteinuria, serum albumin levels that are usually normal, and most importantly, there is no peripheral edema, even when protein excretion exceeds 3 to 4 g/day.[4]
References
- ↑ 1.0 1.1 Rydel JJ, Korbet SM, Borok RZ, Schwartz MM (1995). "Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment". Am J Kidney Dis. 25 (4): 534–42. PMID 7702047.
- ↑ Choy BY, Chan TM, Lai KN (November 2006). "Recurrent glomerulonephritis after kidney transplantation". Am. J. Transplant. 6 (11): 2535–42. doi:10.1111/j.1600-6143.2006.01502.x. PMID 16939521.
- ↑ 3.0 3.1 Chun MJ, Korbet SM, Schwartz MM, Lewis EJ (2004). "Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants". J Am Soc Nephrol. 15 (8): 2169–77. doi:10.1097/01.ASN.0000135051.62500.97. PMID 15284302.
- ↑ Fernandez-Fresnedo G, Segarra A, González E, Alexandru S, Delgado R, Ramos N; et al. (2009). "Rituximab treatment of adult patients with steroid-resistant focal segmental glomerulosclerosis". Clin J Am Soc Nephrol. 4 (8): 1317–23. doi:10.2215/CJN.00570109. PMC 2723972. PMID 19578004.