Leiomyosarcoma pathophysiology: Difference between revisions
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=== Microscopic Pathology === | === Microscopic Pathology === | ||
On microscopic histopathological analysis,prominent cellular atypia, abundant mitoses(15-30 per 10 high power field),and areas of coagulative necrosis are characteristic features of the leiomyosarcoma.Leiomyosarcoma of somatic soft tissue has a number of histologic subtypes including epithelioid leiomyosarcoma, myxoid leiomyosarcoma, inflammatory leiomyosarcoma, granular cell leiomyosarcoma and dedifferentiated leiomyosarcoma.<sup>4</sup> The clinical importance of these subtypes has not been well studied. | On microscopic histopathological analysis,prominent cellular atypia, abundant mitoses(15-30 per 10 high power field),and areas of coagulative necrosis are characteristic features of the leiomyosarcoma.Leiomyosarcoma of somatic soft tissue has a number of histologic subtypes including epithelioid leiomyosarcoma, myxoid leiomyosarcoma, inflammatory leiomyosarcoma, granular cell leiomyosarcoma and dedifferentiated leiomyosarcoma.<sup>4</sup> The clinical importance of these subtypes has not been well studied.<ref name="pmid8179071">Bell SW, Kempson RL, Hendrickson MR (1994) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=8179071 Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases.] ''Am J Surg Pathol'' 18 (6):535-58. PMID: [https://pubmed.gov/8179071 8179071]</ref> | ||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
Revision as of 08:44, 14 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
The pathogenesis of leimyosarcoma is characterized by malignant smoth muscle neoplasm that can appear in any site in the body but most commonly found in the uterus,small intestine and retro peritoneum.[1]
Gross Pathology
On gross pathology, leiomyosarcoma appears to be soft, large, yellow or tan solitary masses with fleshy cut surfaces and areas of hemorrhage and necrosis.
Microscopic Pathology
On microscopic histopathological analysis,prominent cellular atypia, abundant mitoses(15-30 per 10 high power field),and areas of coagulative necrosis are characteristic features of the leiomyosarcoma.Leiomyosarcoma of somatic soft tissue has a number of histologic subtypes including epithelioid leiomyosarcoma, myxoid leiomyosarcoma, inflammatory leiomyosarcoma, granular cell leiomyosarcoma and dedifferentiated leiomyosarcoma.4 The clinical importance of these subtypes has not been well studied.[2]
Microscopic Pathology
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References
- ↑ Arnold LM, Burman SD, O-Yurvati AH (2010) Diagnosis and management of primary pulmonary leiomyosarcoma. J Am Osteopath Assoc 110 (4):244-6. PMID: 20430913
- ↑ Bell SW, Kempson RL, Hendrickson MR (1994) Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases. Am J Surg Pathol 18 (6):535-58. PMID: 8179071