Leiomyosarcoma causes: Difference between revisions
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== Overview: == | == Overview: == | ||
Exact cause of leiomyosarcoma is not clearly evident. | Exact cause of leiomyosarcoma is not clearly evident. | ||
__NOTOC__ | __NOTOC__{{AE}} {{Rekha}} | ||
{{Leiomyosarcoma}} | {{Leiomyosarcoma}} | ||
Revision as of 04:58, 15 July 2018
Overview:
Exact cause of leiomyosarcoma is not clearly evident. Associate Editor(s)-in-Chief: Rekha, M.D.
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Leiomyosarcoma causes On the Web |
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American Roentgen Ray Society Images of Leiomyosarcoma causes |
Causes:
Exact cause of leiomyosarcoma is not clearly evident.However following points are considered regarding causes[1]:
- Although not proven but some reasearchers believes that it could be a malignant transformation of the fibroid( leiomyoma).
- It may arise denovo or can be due to the genomic instability. However molecular mechanism of tumorigenesis driven by genomic and genetic aberration is yet to be elucidated.
- Over expression of the protooncogene C-myc is seen in 50% of the cases.
- Retinobalstoma gene discrepancies are also seen in 90% of cases.
- P16 chromosomal deletion causes loss of tumor suppression and so is involved in the development of leiomyosarcoma.
- P53 gene mutation is also frequently seen in uterine leiomyosarcoma.
References
- ↑ Crystal JS, Korderas K, Schwartzberg D, Tizio SC, Zheng M, Parker G (2018). "Primary Leiomyosarcoma of the Colon: A Report of Two Cases, Review of the Literature, and Association with Immunosuppression for IBD and Rheumatoid Arthritis". Case Rep Surg. 2018: 6824643. doi:10.1155/2018/6824643. PMC 5892970. PMID 29780656.