Urethral cancer pathophysiology: Difference between revisions
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==Microscopic Pathology== | ==Microscopic Pathology== | ||
* [[Female]]<ref name="pmid23608423">{{cite journal |vauthors=Cantiello F, Cicione A, Salonia A, Autorino R, Tucci L, Madeo I, Damiano R |title=Periurethral fibrosis secondary to prostatic inflammation causing lower urinary tract symptoms: a prospective cohort study |journal=Urology |volume=81 |issue=5 |pages=1018–23 |date=May 2013 |pmid=23608423 |doi=10.1016/j.urology.2013.01.053 |url=}}</ref> | * [[Female]]<ref name="pmid23608423">{{cite journal |vauthors=Cantiello F, Cicione A, Salonia A, Autorino R, Tucci L, Madeo I, Damiano R |title=Periurethral fibrosis secondary to prostatic inflammation causing lower urinary tract symptoms: a prospective cohort study |journal=Urology |volume=81 |issue=5 |pages=1018–23 |date=May 2013 |pmid=23608423 |doi=10.1016/j.urology.2013.01.053 |url=}}</ref> | ||
:* The [[female]] [[urethra]] is lined by [[transitional cell]] [[mucosa]] proximally and [[stratified]] [[squamous]] cells distally. Therefore, [[transitional cell carcinoma]] is most common in the [[proximal]] [[urethra]] | :* The [[female]] [[urethra]] is lined by [[transitional cell]] [[mucosa]] proximally and [[stratified]] [[squamous]] cells distally. | ||
:* Therefore, [[transitional cell carcinoma]] is most common in the [[proximal]] [[urethra]] | |||
:* Squamous cell carcinoma predominates in the distal [[urethra]]. | |||
:* [[Adenocarcinoma]] may occur in both locations and arises from [[metaplasia]] of the numerous [[Periurethral phlegmon|periurethral]] [[glands]]. | |||
* [[Male]] | * [[Male]] | ||
:* The [[male]] [[urethra]] is lined by [[transitional]] cells in its [[prostatic]] and [[Membranous glomerulonephritis|membranous]] portion and [[stratified]] [[Columnar epithelia|columnar]] [[epithelium]] to [[stratified squamous epithelium]] in the [[Bulbous nose|bulbous]] and [[Penile discharge|penile]] portions. The [[submucosa]] of the [[urethra]] contains numerous glands. Therefore, [[Urethral cancer|urethral]] cancer in the [[male]] can manifest the histological characteristics of [[transitional cell carcinoma]], [[squamous cell carcinoma]], or [[adenocarcinoma]]. | :* The [[male]] [[urethra]] is lined by [[transitional]] cells in its [[prostatic]] and [[Membranous glomerulonephritis|membranous]] portion and [[stratified]] [[Columnar epithelia|columnar]] [[epithelium]] to [[stratified squamous epithelium]] in the [[Bulbous nose|bulbous]] and [[Penile discharge|penile]] portions. | ||
:* Except for the [[prostatic urethra]], where [[transitional cell carcinoma]] is most common, [[squamous cell carcinoma]] is the predominant [[histology]] of [[urethral]] [[neoplasms]]. [[Transitional cell carcinoma]] of the [[prostatic urethra]] may be associated with [[transitional cell carcinoma]] of the [[bladder]] and/or [[transitional cell]] [[carcinoma]] arising in [[prostatic ducts]]. | :* The [[submucosa]] of the [[urethra]] contains numerous glands. | ||
:* Therefore, [[Urethral cancer|urethral]] cancer in the [[male]] can manifest the histological characteristics of [[transitional cell carcinoma]], [[squamous cell carcinoma]], or [[adenocarcinoma]]. | |||
:* Except for the [[prostatic urethra]], where [[transitional cell carcinoma]] is most common, [[squamous cell carcinoma]] is the predominant [[histology]] of [[urethral]] [[neoplasms]]. | |||
:* [[Transitional cell carcinoma]] of the [[prostatic urethra]] may be associated with [[transitional cell carcinoma]] of the [[bladder]] and/or [[transitional cell]] [[carcinoma]] arising in [[prostatic ducts]]. | |||
==References== | ==References== | ||
Revision as of 17:01, 6 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
The pathophysiology of urethral cancer depends on the histological subtypes.
Microscopic Pathology
- The female urethra is lined by transitional cell mucosa proximally and stratified squamous cells distally.
- Therefore, transitional cell carcinoma is most common in the proximal urethra
- Squamous cell carcinoma predominates in the distal urethra.
- Adenocarcinoma may occur in both locations and arises from metaplasia of the numerous periurethral glands.
- The male urethra is lined by transitional cells in its prostatic and membranous portion and stratified columnar epithelium to stratified squamous epithelium in the bulbous and penile portions.
- The submucosa of the urethra contains numerous glands.
- Therefore, urethral cancer in the male can manifest the histological characteristics of transitional cell carcinoma, squamous cell carcinoma, or adenocarcinoma.
- Except for the prostatic urethra, where transitional cell carcinoma is most common, squamous cell carcinoma is the predominant histology of urethral neoplasms.
- Transitional cell carcinoma of the prostatic urethra may be associated with transitional cell carcinoma of the bladder and/or transitional cell carcinoma arising in prostatic ducts.
References
- ↑ Cantiello F, Cicione A, Salonia A, Autorino R, Tucci L, Madeo I, Damiano R (May 2013). "Periurethral fibrosis secondary to prostatic inflammation causing lower urinary tract symptoms: a prospective cohort study". Urology. 81 (5): 1018–23. doi:10.1016/j.urology.2013.01.053. PMID 23608423.