Leiomyosarcoma medical therapy: Difference between revisions
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==Radiation Therapy== | ==Radiation Therapy== | ||
*'''Radiation therapy:''' This is a cancer treatment to kill cancer cells or keep them from growing by using high-energy x-rays or other types of radiation.Radiotherapy may be a useful adjunct to improve local control or where a cancer is inoperable due to the specific location or possible progression of the malignancy.It can be used postoperative to help treat known or possible residual disease.Radiation therapy can also be used as a palliative care in cases where extensive metastasis has already occurred.<ref name="pmid18378136">Reed NS, Mangioni C, Malmström H, Scarfone G, Poveda A, Pecorelli S et al. (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18378136 Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages I and II: an European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874).] ''Eur J Cancer'' 44 (6):808-18. [http://dx.doi.org/10.1016/j.ejca.2008.01.019 DOI:10.1016/j.ejca.2008.01.019] PMID: [https://pubmed.gov/18378136 18378136]</ref> | *'''Radiation therapy:''' This is a cancer treatment to kill cancer cells or keep them from growing by using high-energy x-rays or other types of radiation.Radiotherapy may be a useful adjunct to improve local control or where a cancer is inoperable due to the specific location or possible progression of the malignancy.It can be used postoperative to help treat known or possible residual disease.Radiation therapy can also be used as a palliative care in cases where extensive metastasis has already occurred.<ref name="pmid18378136">Reed NS, Mangioni C, Malmström H, Scarfone G, Poveda A, Pecorelli S et al. (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18378136 Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages I and II: an European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874).] ''Eur J Cancer'' 44 (6):808-18. [http://dx.doi.org/10.1016/j.ejca.2008.01.019 DOI:10.1016/j.ejca.2008.01.019] PMID: [https://pubmed.gov/18378136 18378136]</ref>Pelvic radiotherapy Adjuvant pelvic radiotherapy has been shown by some to improve disease-free survival rates. Echt et al. 2 reported a 38% disease-free survival rate in women receiving adjuvant radiotherapy compared with 18% in women receiving surgery alone. However, despite the possible benefit in reducing local recurrence rates, there has not been a proven significant impact on overall survival. 7 In addition, as leiomyosarcomas tend to recur outside the pelvis, this further limits any potential advantages of regionally directed radiotherapy | ||
==Palliative treatment== | ==Palliative treatment== | ||
Revision as of 19:02, 27 February 2019
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Leiomyosarcoma Microchapters |
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Treatment |
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Leiomyosarcoma medical therapy On the Web |
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American Roentgen Ray Society Images of Leiomyosarcoma medical therapy |
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Risk calculators and risk factors for Leiomyosarcoma medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Rekha, M.D.
Overview
Leiomyosarcoma treatment consist of multidisciplinary approach and is best carried out at the specialized hospital setting.Patients with leiomyosarcoma have many treatment options. The selection depends on the stage of the tumor. The options are surgery, radiation therapy, chemotherapy, or a combination of these methods. Before treatment starts, ask your health care team about possible side effects and how treatment may change your normal activities. Because cancer treatments often damage healthy cells and tissues, side effects are common. Side effects may not be the same for each person, and they may change from one treatment session to the next.Non surgical treatment options have shown only limited benefit in the treatment of the Leiomyosarcoma and are generally considered to be less responsive of chemotherapy and radiotherapy.It has generally noted that only 40% cases responds to the chemotherapeutic regimens.
Chemotherapy
- Chemotherapy: For individuals, particularly those who have locally advanced, metastatic, or recurrent disease, chemotherapy may also be recommended, possibly in combination with surgical procedures and/or radiation.The treatment is to use drugs to stop the growth of cancer cells either by killing the cells or by stopping them from dividing. Usual drugs include ifosfamide and doxorubicin (Adriamycin).[1][2]
Radiation Therapy
- Radiation therapy: This is a cancer treatment to kill cancer cells or keep them from growing by using high-energy x-rays or other types of radiation.Radiotherapy may be a useful adjunct to improve local control or where a cancer is inoperable due to the specific location or possible progression of the malignancy.It can be used postoperative to help treat known or possible residual disease.Radiation therapy can also be used as a palliative care in cases where extensive metastasis has already occurred.[3]Pelvic radiotherapy Adjuvant pelvic radiotherapy has been shown by some to improve disease-free survival rates. Echt et al. 2 reported a 38% disease-free survival rate in women receiving adjuvant radiotherapy compared with 18% in women receiving surgery alone. However, despite the possible benefit in reducing local recurrence rates, there has not been a proven significant impact on overall survival. 7 In addition, as leiomyosarcomas tend to recur outside the pelvis, this further limits any potential advantages of regionally directed radiotherapy
Palliative treatment
- Palliative treatment: This treatment is used for the patients whose cancer has spread. It may improve the patient's quality of life by controlling the symptoms and complications of this disease.
References
- ↑ Blay JY (2018) Getting up-to-date in the management of soft tissue sarcoma. Future Oncol 14 (10s):3-13. DOI:10.2217/fon-2018-0074 PMID: 29768050
- ↑ (1969) New antiviral drug. Nature 222 (5190):218. PMID: 5778386
- ↑ Reed NS, Mangioni C, Malmström H, Scarfone G, Poveda A, Pecorelli S et al. (2008) Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages I and II: an European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874). Eur J Cancer 44 (6):808-18. DOI:10.1016/j.ejca.2008.01.019 PMID: 18378136