Sideroblastic anemia surgery: Difference between revisions
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==Overview== | ==Overview== | ||
In severe cases, | In severe cases, [[bone marrow]] transplant is the only option with limited information about the success rate. | ||
==Surgery== | ==Surgery== | ||
* Bone marrow transplantation | * [[Hematopoietic stem cell transplantation|Bone marrow transplantation]] | ||
* Liver transplantation | * [[Liver transplantation]] | ||
== Indications == | == Indications == | ||
* Surgery is not the first-line treatment option for patients with sideroblastic anemia. | * Surgery is not the first-line treatment option for patients with sideroblastic anemia.<ref name="pmid27026139">{{cite journal |vauthors=Rouault TA |title=Mitochondrial iron overload: causes and consequences |journal=Curr. Opin. Genet. Dev. |volume=38 |issue= |pages=31–37 |date=June 2016 |pmid=27026139 |pmc=5035716 |doi=10.1016/j.gde.2016.02.004 |url=}}</ref> | ||
* The indications for surgry are | * The [[Indications and usage|indications]] for surgry are | ||
** young patients with congenital sideroblastic anemia,not responsive to pyridoxine | ** young patients with congenital sideroblastic anemia,not responsive to [[pyridoxine]] | ||
** Transfusion dependent patients | ** [[Blood transfusion|Transfusion]] dependent patients | ||
** Liver cirrhosis | ** [[Liver cirrhosis]] | ||
** Iron overload refractory to | ** [[Iron overload disorder|Iron overload]] refractory to | ||
*** Iron chelation therapy | *** [[Iron]] chelation therapy | ||
*** phlebotomy | *** [[phlebotomy]] | ||
== Contraindications == | == Contraindications == | ||
* Patients with organ damage from secondry hemochromatosis. | |||
==References== | ==References== | ||
Revision as of 19:21, 13 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In severe cases, bone marrow transplant is the only option with limited information about the success rate.
Surgery
Indications
- Surgery is not the first-line treatment option for patients with sideroblastic anemia.[1]
- The indications for surgry are
- young patients with congenital sideroblastic anemia,not responsive to pyridoxine
- Transfusion dependent patients
- Liver cirrhosis
- Iron overload refractory to
- Iron chelation therapy
- phlebotomy
Contraindications
- Patients with organ damage from secondry hemochromatosis.
References
- ↑ Rouault TA (June 2016). "Mitochondrial iron overload: causes and consequences". Curr. Opin. Genet. Dev. 38: 31–37. doi:10.1016/j.gde.2016.02.004. PMC 5035716. PMID 27026139.