Paroxysmal nocturnal hemoglobinuria screening: Difference between revisions
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==Overview== | ==Overview== | ||
==Screening== | ==Screening== | ||
* According to the American society of hematology, screening for paroxysmal nocturnal hemolglobinuria is recommended among patients with: | * According to the American society of hematology, screening for paroxysmal nocturnal hemolglobinuria is recommended among patients with:<ref name="pmid16051736">{{cite journal| author=Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R et al.| title=Diagnosis and management of paroxysmal nocturnal hemoglobinuria. | journal=Blood | year= 2005 | volume= 106 | issue= 12 | pages= 3699-709 | pmid=16051736 | doi=10.1182/blood-2005-04-1717 | pmc=1895106 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16051736 }}</ref> | ||
** Hemoglobinuria | |||
** Cytopenia | ** Cytopenia | ||
** Suspected Myelodysplasia | ** Suspected Myelodysplasia | ||
** Negative direct coombs test hemolytic anemia | ** Negative direct coombs test intravascular hemolytic anemia | ||
** Refractory anemia | ** Refractory anemia | ||
** Aplastic anemia | ** Aplastic anemia with no apparent sign of intravascular hemolysis | ||
** Unexplained thrombosis | ** Unexplained thrombosis especially in unusual sites as: | ||
*** Budd-Chiari syndrome | |||
*** Other intra-abdominal sites (eg, mesenteric or portal veins) | |||
*** Cerebral veins | |||
*** Dermal veins | |||
==References== | ==References== | ||
Revision as of 14:28, 15 August 2018
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Paroxysmal nocturnal hemoglobinuria Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Screening
- According to the American society of hematology, screening for paroxysmal nocturnal hemolglobinuria is recommended among patients with:[1]
- Hemoglobinuria
- Cytopenia
- Suspected Myelodysplasia
- Negative direct coombs test intravascular hemolytic anemia
- Refractory anemia
- Aplastic anemia with no apparent sign of intravascular hemolysis
- Unexplained thrombosis especially in unusual sites as:
- Budd-Chiari syndrome
- Other intra-abdominal sites (eg, mesenteric or portal veins)
- Cerebral veins
- Dermal veins
References
- ↑ Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R; et al. (2005). "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.