Sideroblastic anemia causes: Difference between revisions
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==Overview== | ==Overview== | ||
There are no life-threatening causes of sideroblastic anemia, however complications resulting from untreated [[Disease name|sideroblastic anemia]] is common.Common causes of sideroblastic anemia may include, alcoholism, chloramphenicol, isoniazid, copper deficiency (nutritional, zinc-induced, copper chelation), vit B-6 deficiency, X-linked sideroblastic anemia. Less common causes of sideroblastic anemia include myelodysplastic syndrome, autosomal recessive disorders, X-linked sideroblastic anemia. defect in ALAS2, autosomal recessive sideroblastic anemia with mutations in the SLC25A38 gene and genetic syndromes. | There are no life-threatening causes of sideroblastic anemia, however complications resulting from untreated [[Disease name|sideroblastic anemia]] is common.Common causes of sideroblastic [[anemia]] may include, [[alcoholism]], [[chloramphenicol]], [[isoniazid]], [[copper deficiency]] (nutritional, zinc-induced, copper chelation), vit B-6 deficiency, X-linked sideroblastic anemia. Less common causes of sideroblastic anemia include [[myelodysplastic syndrome]], [[Autosomal recessive disorder|autosomal recessive disorders]], X-linked sideroblastic anemia. defect in [[ALAS2]], autosomal recessive sideroblastic anemia with mutations in the [[SLC25A38]] gene and genetic syndromes. | ||
==Causes== | ==Causes== | ||
===Life-threatening Causes=== | ===Life-threatening Causes=== | ||
*There are no life-threatening causes of sideroblastic anemia, however complications resulting from untreated [[Disease name|sideroblastic anemia]] | *There are no life-threatening causes of sideroblastic anemia, however complications resulting from untreated [[Disease name|sideroblastic anemia]] are common. | ||
===Common Causes=== | ===Common Causes=== | ||
Common causes of sideroblastic anemia may include:<ref name="pmid21632840">{{cite journal |vauthors=Cazzola M, Invernizzi R |title=Ring sideroblasts and sideroblastic anemias |journal=Haematologica |volume=96 |issue=6 |pages=789–92 |date=June 2011 |pmid=21632840 |pmc=3105636 |doi=10.3324/haematol.2011.044628 |url=}}</ref><ref name="pmid25064706">{{cite journal |vauthors=Bottomley SS, Fleming MD |title=Sideroblastic anemia: diagnosis and management |journal=Hematol. Oncol. Clin. North Am. |volume=28 |issue=4 |pages=653–70, v |date=August 2014 |pmid=25064706 |doi=10.1016/j.hoc.2014.04.008 |url=}}</ref> | Common causes of sideroblastic anemia may include:<ref name="pmid21632840">{{cite journal |vauthors=Cazzola M, Invernizzi R |title=Ring sideroblasts and sideroblastic anemias |journal=Haematologica |volume=96 |issue=6 |pages=789–92 |date=June 2011 |pmid=21632840 |pmc=3105636 |doi=10.3324/haematol.2011.044628 |url=}}</ref><ref name="pmid25064706">{{cite journal |vauthors=Bottomley SS, Fleming MD |title=Sideroblastic anemia: diagnosis and management |journal=Hematol. Oncol. Clin. North Am. |volume=28 |issue=4 |pages=653–70, v |date=August 2014 |pmid=25064706 |doi=10.1016/j.hoc.2014.04.008 |url=}}</ref> | ||
* | * | ||
*[[Alcoholism]] | *[[Alcoholism]] | ||
*Chloramphenicol | *[[Chloramphenicol]] | ||
*[[Isoniazid]] | *[[Isoniazid]] | ||
*Copper deficiency (nutritional, zinc-induced, copper chelation) | *[[Copper deficiency]] (nutritional, [[zinc]]-induced, copper chelation) | ||
*Vit B-6 deficiency | *Vit B-6 deficiency | ||
*X-linked sideroblastic anemia | *X-linked sideroblastic anemia | ||
| Line 24: | Line 24: | ||
*[[Autosomal recessive]] | *[[Autosomal recessive]] | ||
===Genetic Causes=== | ===Genetic Causes=== | ||
* X-linked sideroblastic anemia. defect in ALAS2.<ref name="pmid29787825">{{cite journal |vauthors=Long Z, Li H, Du Y, Han B |title=Congenital sideroblastic anemia: Advances in gene mutations and pathophysiology |journal=Gene |volume=668 |issue= |pages=182–189 |date=August 2018 |pmid=29787825 |doi=10.1016/j.gene.2018.05.074 |url=}}</ref> | * X-linked sideroblastic anemia. defect in [[ALAS2]].<ref name="pmid29787825">{{cite journal |vauthors=Long Z, Li H, Du Y, Han B |title=Congenital sideroblastic anemia: Advances in gene mutations and pathophysiology |journal=Gene |volume=668 |issue= |pages=182–189 |date=August 2018 |pmid=29787825 |doi=10.1016/j.gene.2018.05.074 |url=}}</ref> | ||
* Autosomal recessive sideroblastic anemia with mutations in the SLC25A38 gene. | * Autosomal recessive sideroblastic anemia with [[Mutation|mutations]] in the [[SLC25A38]] gene. | ||
* Genetic syndromes | * Genetic syndromes | ||
Revision as of 14:40, 14 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.
Overview
There are no life-threatening causes of sideroblastic anemia, however complications resulting from untreated sideroblastic anemia is common.Common causes of sideroblastic anemia may include, alcoholism, chloramphenicol, isoniazid, copper deficiency (nutritional, zinc-induced, copper chelation), vit B-6 deficiency, X-linked sideroblastic anemia. Less common causes of sideroblastic anemia include myelodysplastic syndrome, autosomal recessive disorders, X-linked sideroblastic anemia. defect in ALAS2, autosomal recessive sideroblastic anemia with mutations in the SLC25A38 gene and genetic syndromes.
Causes
Life-threatening Causes
- There are no life-threatening causes of sideroblastic anemia, however complications resulting from untreated sideroblastic anemia are common.
Common Causes
Common causes of sideroblastic anemia may include:[1][2]
- Alcoholism
- Chloramphenicol
- Isoniazid
- Copper deficiency (nutritional, zinc-induced, copper chelation)
- Vit B-6 deficiency
- X-linked sideroblastic anemia
Less Common Causes
Less common causes of sideroblastic anemia include:
Genetic Causes
- X-linked sideroblastic anemia. defect in ALAS2.[3]
- Autosomal recessive sideroblastic anemia with mutations in the SLC25A38 gene.
- Genetic syndromes
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | Lead poisoning, zinc |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Chloramphenicol,Isoniazid
cycloserine, linezolid, |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | X-linked sideroblastic anemia.
Autosomal recessive sideroblastic . Genetic syndromes |
| Hematologic | Myelodysplastic syndrome |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | Vit B-6 deficiency |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | Alcohol |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order:
- Alcohol
- Vit B-6 def
- Chloromphenicol
- Copper deficiency
- Cause 5
- Cause 6
- Cause 7
- Cause 8
- isoniazid
- Cause 10
References
- ↑ Cazzola M, Invernizzi R (June 2011). "Ring sideroblasts and sideroblastic anemias". Haematologica. 96 (6): 789–92. doi:10.3324/haematol.2011.044628. PMC 3105636. PMID 21632840.
- ↑ Bottomley SS, Fleming MD (August 2014). "Sideroblastic anemia: diagnosis and management". Hematol. Oncol. Clin. North Am. 28 (4): 653–70, v. doi:10.1016/j.hoc.2014.04.008. PMID 25064706.
- ↑ Long Z, Li H, Du Y, Han B (August 2018). "Congenital sideroblastic anemia: Advances in gene mutations and pathophysiology". Gene. 668: 182–189. doi:10.1016/j.gene.2018.05.074. PMID 29787825.