Disseminated intravascular coagulation history and symptoms: Difference between revisions
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Symptoms of DIC vary depending on the magnitude of the imbalance of hemostasis, type of the disease, and the underlying cause. Common manifestations of DIC include bleeding and/or thrombosis with the resulting end organ damage. Patients with acute DIC typically present with bleeding symptoms ranging from oozing from venipuncture sites, petechiae, and ecchymoses; whereas chronic DIC is often associated with hypercoagulable states and thromboembolic complications. | Symptoms of DIC vary depending on the magnitude of the imbalance of hemostasis, type of the disease, and the underlying cause. Common manifestations of DIC include bleeding and/or thrombosis with the resulting end organ damage. Patients with acute DIC typically present with bleeding symptoms ranging from oozing from venipuncture sites, petechiae, and ecchymoses; whereas chronic DIC is often associated with hypercoagulable states and thromboembolic complications. | ||
===Bleeding Symptoms | === Bleeding Symptoms <ref name="pmid580488">{{cite journal |vauthors=Siegal T, Seligsohn U, Aghai E, Modan M |title=Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases |journal=Thromb. Haemost. |volume=39 |issue=1 |pages=122–34 |date=February 1978 |pmid=580488 |doi= |url=}}</ref><ref name="pmid1531791">{{cite journal |vauthors=Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, Marey A, Lestavel P |title=Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies |journal=Chest |volume=101 |issue=3 |pages=816–23 |date=March 1992 |pmid=1531791 |doi= |url=}}</ref> === | ||
* Petechiae | * Petechiae | ||
* Ecchymoses | * Ecchymoses | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History
Symptoms
Symptoms of DIC vary depending on the magnitude of the imbalance of hemostasis, type of the disease, and the underlying cause. Common manifestations of DIC include bleeding and/or thrombosis with the resulting end organ damage. Patients with acute DIC typically present with bleeding symptoms ranging from oozing from venipuncture sites, petechiae, and ecchymoses; whereas chronic DIC is often associated with hypercoagulable states and thromboembolic complications.
Bleeding Symptoms [1][2]
- Petechiae
- Ecchymoses
- Blood oozing from wound sites, intravenous lines, catheters, mucosal surfaces
- Hemorrhage involving gastrointestinal tract, lungs, or central nervous system
Thrombosis Symptoms
- Venous thromboembolism
- Arterial thrombosis with tissue or organ ischemia
- Cerebral embolism
Organ Dysfunction
- Symptoms of acute kidney injury
- Decreased urinary output
- Edema
- Nausea
- Fatigue
- Symptoms of hepatic dysfunction
- Jaundice
- Nausea
- Abdominal pain and swelling
- Symptoms of acute lung injury
- Hemoptysis
- Dyspnea
- Symptoms of neurologic dysfunction
- Coma
- Delirium
- Focal neurologic deficits
- Symptoms of adrenal insufficiency
- Fatigue
- Nausea
- Low blood pressure
- Altered mental status
References
- ↑ Siegal T, Seligsohn U, Aghai E, Modan M (February 1978). "Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases". Thromb. Haemost. 39 (1): 122–34. PMID 580488.
- ↑ Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, Marey A, Lestavel P (March 1992). "Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies". Chest. 101 (3): 816–23. PMID 1531791.