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* Myelodysplastic Syndrome
* Myelodysplastic Syndrome
* Secondary Thrombocytosis
* Secondary Thrombocytosis
{|
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
! colspan="2" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
| colspan="6" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical manifestations'''
! colspan="8" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
| colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Gold standard'''
|-
| colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Symptoms'''
! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical examination
|-
! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pallor
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Weakness
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatomegaly
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Growth retardation
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Peripheral blood smear
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum iron
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum TIBC
!Serum ferritin
g/L
!Iron in erythroblasts
!Iron stores in bone marrow
|-
|
|Sideroblastic anemia
| +
| +
|
|
|
|
|variable
|Normal -high
| colspan="3" |Normal
|50-300
|present in ring form
|present
|
|-
| rowspan="5" style="background: #DCDCDC; padding: 5px; text-align: center;" |Microcytic hypochromic
anemia
|Iron deficiency anemia
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |microcytic/
hypochromic
| style="background: #F5F5F5; padding: 5px;" |<30
| colspan="3" style="background: #F5F5F5; padding: 5px;" |> 360
|<15
|absent
|absent
| style="background: #F5F5F5; padding: 5px;" |
|-
|Thalasemia
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |jaundice
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" |Hpatomegaly
| style="background: #F5F5F5; padding: 5px;" |Splenomegaly
| style="background: #F5F5F5; padding: 5px;" |Growth retardation
| style="background: #F5F5F5; padding: 5px;" |micro/hypo with targeting
| style="background: #F5F5F5; padding: 5px;" |Normal -high
| colspan="3" style="background: #F5F5F5; padding: 5px;" |Normal
|50-300
|present
|present
| style="background: #F5F5F5; padding: 5px;" |
|-
|Anemia of chronic disease
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |Normal
| style="background: #F5F5F5; padding: 5px;" |Low
| colspan="3" style="background: #F5F5F5; padding: 5px;" |<300
|30-200
|absent
|present
| style="background: #F5F5F5; padding: 5px;" |
|-
|Lead poisoning
|
|
|
|
|
|
|
|
| colspan="3" |
|
|
|
|
|-
|Blood loss
|
|
|
|
|
|
|
|
| colspan="3" |
|
|
|
|
|-
| rowspan="3" style="background: #DCDCDC; padding: 5px; text-align: center;" |Tissue iron overload
|
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|
|
|
|
|
| style="background: #F5F5F5; padding: 5px;" |
|-
|
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|
|
|
|
|
| style="background: #F5F5F5; padding: 5px;" |
|-
|
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|
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| style="background: #F5F5F5; padding: 5px;" |
|}


==References==
==References==

Revision as of 18:04, 19 September 2018

Sideroblastic anemia Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Sideroblastic Anemia from other Diseases

Epidemiology and Demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.


Overview

Differential Diagnosis

Sideroblastic anemia must be differentiated from other causes of microcytic hypochromic anemia: iron deficiency anemia, thalassemia, anemia of chronic disease, lead poisoning, and blood loss.

• Tissue iron overload from sideroblastic anemia may act similar to hereditary hemochromatosis with liver cirrhosis, diabetes, congestive heart failure, and cardiac arrhythmias.

  • ALA Dehydratase Deficiency Porphyria
  • Acute Myeloid Leukemia (AML)
  • Congenital Erythropoietic Porphyria
  • Hereditary Coproporphyria
  • Iron Deficiency Anemia
  • Myelodysplastic Syndrome
  • Secondary Thrombocytosis

References

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