Hamartoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Hamartomas may be classified into different types based on their location, such as: lung (most common), heart, hypothalamus, kidneys, or spleen. Other classifications can consider lesion class, dividing hamartomas into 4 different categories, such as: bone-forming, cartilage-forming, fiber-forming, and benign non–matrix-forming.

Classification

Location

Based on the location, hamartomas can be classified into the following types:

Location	Type
CNS	Hypothalamic hamartoma Neurofibromatosis in von Recklinghausen disease Neuroepithelial cells in tuberous sclerosis
Lung	Endobronchial pulmonary hamartoma Parenchymal pulmonary hamartoma Bronchial hamartoma
Heart	Rhabdomyoma
Bowel	Peutz-Jeghers polyp Polyp of the large bowel
Kidneys	Angiomyolipoma
Spleen	Splenic hamartoma
Skin	Melanocytic nevi

Lesion class

Based on the lesion class, hamartomas can be classified into the following types:

Lesion class	Tumors type
Cartilage-forming	Enchondromatosis Epiphyseal osteochondroma Multiple osteochondroma Osteochondroma
Fiber-forming	Nonossifying fibroma Fibrous dysplasia
Bone-forming	Osteopathia striata Melorheostosis Osteopoikilosis Bone island
Benign non-matrix-forming	Skeletal hemangiomatosis Hemangioma of bone

• Bone-forming tumors

• Cartilage-forming tumors

• Fiber-forming tumors
  • Nonossifying fibroma
  • Fibrous dysplasia
  • Mazabraud syndrome

• Benign non–matrix-forming tumors