Paroxysmal nocturnal hemoglobinuria history and symptoms

Paroxysmal nocturnal hemoglobinuria Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Associate Editor(s)-in-Chief:

History and Symptoms

History

Patients with PNH may have a positive history of:

• Feeling tired/ weak
• Shortness of breath
• Dark colored urine
• Jaundice
• Blood clots
• Difficulty swallowing
• Chest pain
• Abdominal pain
• Headaches
• Confusion
• Dysphagia
• Erectile dysfunction
• Low blood cell counts
• Iron deficiency

Common Symptoms

Common symptoms of PNH include:

• Due to hemolysis
  1. Fatigue
  2. Dyspnea
  3. Jaundice

• Due to thrombosis:
  1. Headaches
  2. Confusion
  3. Abdominal pain
  4. Chest pain

• Due to nitric oxide depletion:
  1. Dysphagia
  2. Chest pain
  3. Abdominal pain
  4. Erectile dysfunction

Less Common Symptoms

Less common symptoms of PNH include:

• Necrotic skin lesions