Hairy cell leukemia differential diagnosis: Difference between revisions
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* Hairy cell leukemia must also be differentiated from other causes of fever, splenomegaly, and fatigue such as:<ref name="pmid15016649">{{cite journal |vauthors=Vanhentenrijk V, De Wolf-Peeters C, Wlodarska I |title=Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature |journal=Blood |volume=104 |issue=1 |pages=250–5 |date=July 2004 |pmid=15016649 |doi=10.1182/blood-2004-01-0181 |url=}}</ref> | * Hairy cell leukemia must also be differentiated from other causes of fever, splenomegaly, and fatigue such as:<ref name="pmid9915494">{{cite journal |vauthors=Duggan DJ, Bittner M, Chen Y, Meltzer P, Trent JM |title=Expression profiling using cDNA microarrays |journal=Nat. Genet. |volume=21 |issue=1 Suppl |pages=10–4 |date=January 1999 |pmid=9915494 |doi=10.1038/4434 |url=}}</ref><ref name="pmid15016649">{{cite journal |vauthors=Vanhentenrijk V, De Wolf-Peeters C, Wlodarska I |title=Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature |journal=Blood |volume=104 |issue=1 |pages=250–5 |date=July 2004 |pmid=15016649 |doi=10.1182/blood-2004-01-0181 |url=}}</ref> | ||
:* Aplastic anemia | :* Aplastic anemia | ||
:* Myelodysplastic syndrome | :* Myelodysplastic syndrome | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
- Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
Differenting Hairy cell leukemia from other Diseases
- Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.[1]
| Differential Diagnosis | Surface Immunoglobulin | CD5 | CD22/FMC7 | CD23 | CD79b | CD103 |
|---|---|---|---|---|---|---|
|
Hairy cell leukaemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive/Negative |
Positive |
|
Chronic lymphocytic leukaemia |
Weakly positive |
Positive |
Negative |
Positive |
Negative |
Positive/Negative |
|
Prolymphocytic leukaemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive |
Negative |
|
Mantle cell lymphoma |
Positive |
Positive |
Strongly positive |
Negative |
Strongly positive |
Negative |
|
Follicular lymphoma |
Strongly positive |
Negative |
Positive |
Negative |
Strongly positive |
Negative |
- Hairy cell leukemia must also be differentiated from other causes of fever, splenomegaly, and fatigue such as:[2][3]
- Aplastic anemia
- Myelodysplastic syndrome
- Splenic marginal zone lymphoma
- B-cell prolymphocytic leukemia
- Idiopathic myelofibrosis
References
- ↑ Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011
- ↑ Duggan DJ, Bittner M, Chen Y, Meltzer P, Trent JM (January 1999). "Expression profiling using cDNA microarrays". Nat. Genet. 21 (1 Suppl): 10–4. doi:10.1038/4434. PMID 9915494.
- ↑ Vanhentenrijk V, De Wolf-Peeters C, Wlodarska I (July 2004). "Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature". Blood. 104 (1): 250–5. doi:10.1182/blood-2004-01-0181. PMID 15016649.