Mantle cell lymphoma classification: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{ Mantle cell lymphoma }} | {{Mantle cell lymphoma }} | ||
{{CMG}}; {{AE}} {{Akram}} | {{CMG}}; {{AE}} {{Akram}} | ||
==Overview== | ==Overview== | ||
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==Classification== | ==Classification== | ||
=== Classical MCL: === | |||
* Classical MCL typically consists of immunoglobulin heavy-chain variable region gene(IGHV)-unmutated or minimally mutated B cells that usually express SOX11. | |||
* Classical MCL usually involves the lymph nodes and other extranodal sites. | |||
* However, these cells can acquire further molecular and cytogenetic abnormalities leading to the more aggressive: | |||
*#Blastoid MCL | |||
*#Pleomorphic MCL | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 17:42, 6 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2]
Overview
According to the revised 2016 World Health Organization classification of lymphoid neoplasms, mantle cell lymphoma(MCL) can be broadly classified into three types:
- Classical MCL.
- Leukemic nonnodal MCL.
- In-situ mantle cell neoplasia (ISMCN).
Classification
Classical MCL:
- Classical MCL typically consists of immunoglobulin heavy-chain variable region gene(IGHV)-unmutated or minimally mutated B cells that usually express SOX11.
- Classical MCL usually involves the lymph nodes and other extranodal sites.
- However, these cells can acquire further molecular and cytogenetic abnormalities leading to the more aggressive:
- Blastoid MCL
- Pleomorphic MCL