Hairy cell leukemia differential diagnosis: Difference between revisions
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==Differentiating Hairy cell leukemia from other Diseases== | ==Differentiating Hairy cell leukemia from other Diseases== | ||
* Hairy cell leukemia must be differentiated from other diseases that cause [[weight loss]], [[fatigue]], [[splenomegaly]], and fever, such as [[chronic lymphocytic leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="pmid29110361">{{cite journal |vauthors=Troussard X, Cornet E |title=Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment |journal=Am. J. Hematol. |volume=92 |issue=12 |pages=1382–1390 |date=December 2017 |pmid=29110361 |pmc=5698705 |doi=10.1002/ajh.24936 |url=}}</ref> | * Hairy cell leukemia must be differentiated from other diseases that cause [[weight loss]], [[fatigue]], [[splenomegaly]], and fever, such as [[chronic lymphocytic leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="pmid29110361">{{cite journal |vauthors=Troussard X, Cornet E |title=Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment |journal=Am. J. Hematol. |volume=92 |issue=12 |pages=1382–1390 |date=December 2017 |pmid=29110361 |pmc=5698705 |doi=10.1002/ajh.24936 |url=}}</ref><ref name="pmid2364167">{{cite journal |vauthors=Sainati L, Matutes E, Mulligan S, de Oliveira MP, Rani S, Lampert IA, Catovsky D |title=A variant form of hairy cell leukemia resistant to alpha-interferon: clinical and phenotypic characteristics of 17 patients |journal=Blood |volume=76 |issue=1 |pages=157–62 |date=July 1990 |pmid=2364167 |doi= |url=}}</ref> | ||
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Revision as of 04:30, 8 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
- Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
Differentiating Hairy cell leukemia from other Diseases
- Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.[1][2]
| Differential Diagnosis | Surface Immunoglobulin | CD5 | CD22/FMC7 | CD23 | CD79b | CD103 |
|---|---|---|---|---|---|---|
|
Hairy cell leukaemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive/Negative |
Positive |
|
Chronic lymphocytic leukaemia |
Weakly positive |
Positive |
Negative |
Positive |
Negative |
Positive/Negative |
|
Prolymphocytic leukaemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive |
Negative |
|
Mantle cell lymphoma |
Positive |
Positive |
Strongly positive |
Negative |
Strongly positive |
Negative |
|
Follicular lymphoma |
Strongly positive |
Negative |
Positive |
Negative |
Strongly positive |
Negative |
- Hairy cell leukemia must also be differentiated from other causes of fever, splenomegaly, and fatigue such as:[3][4]
- Aplastic anemia
- Myelodysplastic syndrome
- Splenic marginal zone lymphoma
- B-cell prolymphocytic leukemia
- Idiopathic myelofibrosis
References
- ↑ Troussard X, Cornet E (December 2017). "Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment". Am. J. Hematol. 92 (12): 1382–1390. doi:10.1002/ajh.24936. PMC 5698705. PMID 29110361.
- ↑ Sainati L, Matutes E, Mulligan S, de Oliveira MP, Rani S, Lampert IA, Catovsky D (July 1990). "A variant form of hairy cell leukemia resistant to alpha-interferon: clinical and phenotypic characteristics of 17 patients". Blood. 76 (1): 157–62. PMID 2364167.
- ↑ Duggan DJ, Bittner M, Chen Y, Meltzer P, Trent JM (January 1999). "Expression profiling using cDNA microarrays". Nat. Genet. 21 (1 Suppl): 10–4. doi:10.1038/4434. PMID 9915494.
- ↑ Vanhentenrijk V, De Wolf-Peeters C, Wlodarska I (July 2004). "Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature". Blood. 104 (1): 250–5. doi:10.1182/blood-2004-01-0181. PMID 15016649.