Mantle cell lymphoma causes: Difference between revisions
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The causes of [[mantle cell lymphoma]] have not been clearly identified. | The causes of [[mantle cell lymphoma]] have not been clearly identified. | ||
==Causes== | ==Causes== | ||
* [[Mantle cell lymphoma]] | * [[Mantle cell lymphoma]] is usually caused when the somatic cells acquire non-inherited [[genetic mutations]]. | ||
* The typical [[mutation]] occurring in [[mantle cell lymphoma]] due to the “[[reciprocal translocation]]” between [[chromosome 11]] and [[chromosome 14]] t(11;14) causes the over expression of [[cyclin D1]] which results in uncontrolled growth of [[B cells]] leading to [[lymphoma]] development. | * The typical [[mutation]] occurring in [[mantle cell lymphoma]] due to the “[[reciprocal translocation]]” between [[chromosome 11]] and [[chromosome 14]] t(11;14) causes the over expression of [[cyclin D1]] which results in uncontrolled growth of [[B cells]] leading to [[lymphoma]] development. | ||
However, factors that initiate the [[genetic]] alterations are typically not identifiable, and usually occur in people with no particular risk factors for [[lymphoma]] development. | However, factors that initiate the [[genetic]] alterations are typically not identifiable, and usually occur in people with no particular risk factors for [[lymphoma]] development. |
Revision as of 17:57, 14 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
The causes of mantle cell lymphoma have not been clearly identified.
Causes
- Mantle cell lymphoma is usually caused when the somatic cells acquire non-inherited genetic mutations.
- The typical mutation occurring in mantle cell lymphoma due to the “reciprocal translocation” between chromosome 11 and chromosome 14 t(11;14) causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development.
However, factors that initiate the genetic alterations are typically not identifiable, and usually occur in people with no particular risk factors for lymphoma development.