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* [[Mantle cell lymphoma]] is usually caused when the somatic cells acquire non-inherited [[genetic mutations]].
* [[Mantle cell lymphoma]] is usually caused when the somatic cells acquire non-inherited [[genetic mutations]].
* The typical [[mutation]] occurring in [[mantle cell lymphoma]] due to the “[[reciprocal translocation]]” between [[chromosome 11]] and [[chromosome 14]] t(11;14) causes the over expression of [[cyclin D1]] which results in uncontrolled growth of [[B cells]] leading to [[lymphoma]] development.  
* The typical [[mutation]] occurring in [[mantle cell lymphoma]] due to the “[[reciprocal translocation]]” between [[chromosome 11]] and [[chromosome 14]] t(11;14) causes the over expression of [[cyclin D1]] which results in uncontrolled growth of [[B cells]] leading to [[lymphoma]] development.  
However, factors that initiate the [[genetic]] alterations are typically not identifiable, and usually occur in people with no particular risk factors for [[lymphoma]] development.
However, the inititating factors of these [[genetic]] alterations are generally not identifiable. People with no particular risk factors for [[lymphoma]] development are commonly affected by these alterations


==References==
==References==

Revision as of 18:03, 14 November 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

The causes of mantle cell lymphoma have not been clearly identified.

Causes

However, the inititating factors of these genetic alterations are generally not identifiable. People with no particular risk factors for lymphoma development are commonly affected by these alterations

References

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