Hairy cell leukemia laboratory tests: Difference between revisions
Jump to navigation
Jump to search
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of [[hairy cell leukemia]] include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like [[cytoplasmic]] extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia. | Laboratory findings consistent with the diagnosis of [[hairy cell leukemia]] include abnormal [[complete blood count]], [[immunohistochemistry]], and flow cytometry. The presence of hairy cells with thread-like [[cytoplasmic]] extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of [[hairy cell leukemia]] include: | Laboratory findings consistent with the diagnosis of [[hairy cell leukemia]] include:<ref name="pmid7519510">{{cite journal |vauthors=Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V |title=Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia |journal=Leuk. Lymphoma |volume=13 |issue=3-4 |pages=307–16 |date=April 1994 |pmid=7519510 |doi=10.3109/10428199409056295 |url=}}</ref> | ||
=== Complete Blood Count === | |||
===Complete Blood Count=== | * [[Anemia]] - Decreased [[hemoglobin]] concentration<ref name="pub">{{cite journal |vauthors=Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R |title=Hairy cell leukemia: A decade long experience of North Indian Hematology Center |journal=Indian J Med Paediatr Oncol |volume=35 |issue=4 |pages=271–5 |year=2014 |pmid=25538404 |pmc=4264273 |doi=10.4103/0971-5851.144988 |url=}}</ref> | ||
* Anemia - Decreased [[hemoglobin]] concentration<ref name="pub">{{cite journal |vauthors=Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R |title=Hairy cell leukemia: A decade long experience of North Indian Hematology Center |journal=Indian J Med Paediatr Oncol |volume=35 |issue=4 |pages=271–5 |year=2014 |pmid=25538404 |pmc=4264273 |doi=10.4103/0971-5851.144988 |url=}}</ref> | * [[Thrombocytopenia]] - Decreased [[platelets]] count | ||
* Thrombocytopenia - Decreased [[platelets]] count | |||
* Decreased [[WBC]] count | * Decreased [[WBC]] count | ||
* Neutropenia | * [[Neutropenia]] | ||
* Elevated BUN(Blood urea nitrogen) | * Elevated [[Blood urea nitrogen|BUN]](Blood urea nitrogen) | ||
* Abnormal liver function tests | * Abnormal [[liver function tests]] | ||
* Hypergammaglobulinemia may be positive in small percentage of patients with [[hairy cell leukemia]] | * [[Hypergammaglobulinemia]] may be positive in small percentage of patients with [[hairy cell leukemia]] | ||
* Leukocytosis | * Leukocytosis | ||
* Monocytopenia | |||
===Blood Smear=== | ===Blood Smear=== | ||
Revision as of 17:26, 16 November 2018
|
Hairy cell leukemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Hairy cell leukemia laboratory tests On the Web |
|
American Roentgen Ray Society Images of Hairy cell leukemia laboratory tests |
|
Risk calculators and risk factors for Hairy cell leukemia laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of hairy cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like cytoplasmic extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia.
Laboratory Findings
Laboratory findings consistent with the diagnosis of hairy cell leukemia include:[1]
Complete Blood Count
- Anemia - Decreased hemoglobin concentration[2]
- Thrombocytopenia - Decreased platelets count
- Decreased WBC count
- Neutropenia
- Elevated BUN(Blood urea nitrogen)
- Abnormal liver function tests
- Hypergammaglobulinemia may be positive in small percentage of patients with hairy cell leukemia
- Leukocytosis
- Monocytopenia
Blood Smear
- Hairy cells with thread-like cytoplasmic extensions[2]
- Positive TRAP stain
Immunohistochemistry
- On immunohistochemistry, characteristic findings of hairy cell leukemia include:[2]
- Annexin A1 +ve
- CD20 +ve
- CD25 +ve
- CD103 +ve
Flow Cytometry
- On flow cytometry, characteristic findings of hairy cell leukemia include:[2]
References
- ↑ Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V (April 1994). "Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia". Leuk. Lymphoma. 13 (3–4): 307–16. doi:10.3109/10428199409056295. PMID 7519510.
- ↑ 2.0 2.1 2.2 2.3 Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.