Hairy cell leukemia laboratory tests: Difference between revisions
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===Blood Smear=== | ===Blood Smear=== | ||
* Hairy cells with thread-like [[cytoplasmic]] extensions | * Hairy cells with thread-like [[cytoplasmic]] extensions | ||
* Positive TRAP stain | * Positive TRAP stain | ||
===Immunohistochemistry=== | ===Immunohistochemistry=== | ||
* On immunohistochemistry, characteristic findings of hairy cell leukemia include: | * On immunohistochemistry, characteristic findings of hairy cell leukemia include: | ||
:* [[Annexin A1]] +ve | :* [[Annexin A1]] +ve | ||
:* [[CD20]] +ve | :* [[CD20]] +ve | ||
| Line 32: | Line 32: | ||
===Flow Cytometry=== | ===Flow Cytometry=== | ||
* On flow cytometry, characteristic findings of hairy cell leukemia include: | * On flow cytometry, characteristic findings of hairy cell leukemia include: | ||
:* [[CD19]] +ve | :* [[CD19]] +ve | ||
:* [[CD11c]] +ve | :* [[CD11c]] +ve | ||
Revision as of 17:30, 16 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of hairy cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like cytoplasmic extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia.
Laboratory Findings
Laboratory findings consistent with the diagnosis of hairy cell leukemia include:[1][2]
Complete Blood Count
- Anemia - Decreased hemoglobin concentration[3]
- Thrombocytopenia - Decreased platelets count
- Decreased WBC count
- Neutropenia
- Elevated BUN(Blood urea nitrogen)
- Abnormal liver function tests
- Hypergammaglobulinemia may be positive in small percentage of patients with hairy cell leukemia
- Leukocytosis
- Monocytopenia
Blood Smear
- Hairy cells with thread-like cytoplasmic extensions
- Positive TRAP stain
Immunohistochemistry
- On immunohistochemistry, characteristic findings of hairy cell leukemia include:
- Annexin A1 +ve
- CD20 +ve
- CD25 +ve
- CD103 +ve
Flow Cytometry
- On flow cytometry, characteristic findings of hairy cell leukemia include:
References
- ↑ Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V (April 1994). "Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia". Leuk. Lymphoma. 13 (3–4): 307–16. doi:10.3109/10428199409056295. PMID 7519510.
- ↑ Golomb HM, Catovsky D, Golde DW (November 1978). "Hairy cell leukemia: a clinical review based on 71 cases". Ann. Intern. Med. 89 (5 Pt 1): 677–83. PMID 717940.
- ↑ Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.