Hairy cell leukemia laboratory tests: Difference between revisions

Jump to navigation Jump to search
← Older editNewer edit →
VisualWikitext
Gunnam (talk | contribs)
nocaptcha, Administrators
8,766 edits
Gunnam (talk | contribs)
nocaptcha, Administrators
8,766 edits
Line 7: Line 7:


==Laboratory Findings==
==Laboratory Findings==
Laboratory findings consistent with the diagnosis of [[hairy cell leukemia]] include:<ref name="pmid7519510">{{cite journal |vauthors=Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V |title=Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia |journal=Leuk. Lymphoma |volume=13 |issue=3-4 |pages=307–16 |date=April 1994 |pmid=7519510 |doi=10.3109/10428199409056295 |url=}}</ref><ref name="pmid717940">{{cite journal |vauthors=Golomb HM, Catovsky D, Golde DW |title=Hairy cell leukemia: a clinical review based on 71 cases |journal=Ann. Intern. Med. |volume=89 |issue=5 Pt 1 |pages=677–83 |date=November 1978 |pmid=717940 |doi= |url=}}</ref>
Laboratory findings consistent with the diagnosis of [[hairy cell leukemia]] include:<ref name="GreverAbdel-Wahab20174">{{cite journal|last1=Grever|first1=Michael R.|last2=Abdel-Wahab|first2=Omar|last3=Andritsos|first3=Leslie A.|last4=Banerji|first4=Versha|last5=Barrientos|first5=Jacqueline|last6=Blachly|first6=James S.|last7=Call|first7=Timothy G.|last8=Catovsky|first8=Daniel|last9=Dearden|first9=Claire|last10=Demeter|first10=Judit|last11=Else|first11=Monica|last12=Forconi|first12=Francesco|last13=Gozzetti|first13=Alessandro|last14=Ho|first14=Anthony D.|last15=Johnston|first15=James B.|last16=Jones|first16=Jeffrey|last17=Juliusson|first17=Gunnar|last18=Kraut|first18=Eric|last19=Kreitman|first19=Robert J.|last20=Larratt|first20=Loree|last21=Lauria|first21=Francesco|last22=Lozanski|first22=Gerard|last23=Montserrat|first23=Emili|last24=Parikh|first24=Sameer A.|last25=Park|first25=Jae H.|last26=Polliack|first26=Aaron|last27=Quest|first27=Graeme R.|last28=Rai|first28=Kanti R.|last29=Ravandi|first29=Farhad|last30=Robak|first30=Tadeusz|last31=Saven|first31=Alan|last32=Seymour|first32=John F.|last33=Tadmor|first33=Tamar|last34=Tallman|first34=Martin S.|last35=Tam|first35=Constantine|last36=Tiacci|first36=Enrico|last37=Troussard|first37=Xavier|last38=Zent|first38=Clive S.|last39=Zenz|first39=Thorsten|last40=Zinzani|first40=Pier Luigi|last41=Falini|first41=Brunangelo|title=Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia|journal=Blood|volume=129|issue=5|year=2017|pages=553–560|issn=0006-4971|doi=10.1182/blood-2016-01-689422}}</ref><ref name="pmid7519510">{{cite journal |vauthors=Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V |title=Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia |journal=Leuk. Lymphoma |volume=13 |issue=3-4 |pages=307–16 |date=April 1994 |pmid=7519510 |doi=10.3109/10428199409056295 |url=}}</ref><ref name="pmid717940">{{cite journal |vauthors=Golomb HM, Catovsky D, Golde DW |title=Hairy cell leukemia: a clinical review based on 71 cases |journal=Ann. Intern. Med. |volume=89 |issue=5 Pt 1 |pages=677–83 |date=November 1978 |pmid=717940 |doi= |url=}}</ref>


=== Complete Blood Count ===
=== Complete Blood Count ===
Line 21: Line 21:


===Blood Smear===
===Blood Smear===
* Hairy cells with thread-like [[cytoplasmic]] extensions
* Hairy cells with thread-like [[cytoplasmic]] extensions<ref name="GreverAbdel-Wahab20173">{{cite journal|last1=Grever|first1=Michael R.|last2=Abdel-Wahab|first2=Omar|last3=Andritsos|first3=Leslie A.|last4=Banerji|first4=Versha|last5=Barrientos|first5=Jacqueline|last6=Blachly|first6=James S.|last7=Call|first7=Timothy G.|last8=Catovsky|first8=Daniel|last9=Dearden|first9=Claire|last10=Demeter|first10=Judit|last11=Else|first11=Monica|last12=Forconi|first12=Francesco|last13=Gozzetti|first13=Alessandro|last14=Ho|first14=Anthony D.|last15=Johnston|first15=James B.|last16=Jones|first16=Jeffrey|last17=Juliusson|first17=Gunnar|last18=Kraut|first18=Eric|last19=Kreitman|first19=Robert J.|last20=Larratt|first20=Loree|last21=Lauria|first21=Francesco|last22=Lozanski|first22=Gerard|last23=Montserrat|first23=Emili|last24=Parikh|first24=Sameer A.|last25=Park|first25=Jae H.|last26=Polliack|first26=Aaron|last27=Quest|first27=Graeme R.|last28=Rai|first28=Kanti R.|last29=Ravandi|first29=Farhad|last30=Robak|first30=Tadeusz|last31=Saven|first31=Alan|last32=Seymour|first32=John F.|last33=Tadmor|first33=Tamar|last34=Tallman|first34=Martin S.|last35=Tam|first35=Constantine|last36=Tiacci|first36=Enrico|last37=Troussard|first37=Xavier|last38=Zent|first38=Clive S.|last39=Zenz|first39=Thorsten|last40=Zinzani|first40=Pier Luigi|last41=Falini|first41=Brunangelo|title=Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia|journal=Blood|volume=129|issue=5|year=2017|pages=553–560|issn=0006-4971|doi=10.1182/blood-2016-01-689422}}</ref>
* Positive TRAP stain
* Positive TRAP stain


===Immunohistochemistry===
===Immunohistochemistry===
* On immunohistochemistry, characteristic findings of hairy cell leukemia include:
* On immunohistochemistry, characteristic findings of hairy cell leukemia include:<ref name="GreverAbdel-Wahab20172">{{cite journal|last1=Grever|first1=Michael R.|last2=Abdel-Wahab|first2=Omar|last3=Andritsos|first3=Leslie A.|last4=Banerji|first4=Versha|last5=Barrientos|first5=Jacqueline|last6=Blachly|first6=James S.|last7=Call|first7=Timothy G.|last8=Catovsky|first8=Daniel|last9=Dearden|first9=Claire|last10=Demeter|first10=Judit|last11=Else|first11=Monica|last12=Forconi|first12=Francesco|last13=Gozzetti|first13=Alessandro|last14=Ho|first14=Anthony D.|last15=Johnston|first15=James B.|last16=Jones|first16=Jeffrey|last17=Juliusson|first17=Gunnar|last18=Kraut|first18=Eric|last19=Kreitman|first19=Robert J.|last20=Larratt|first20=Loree|last21=Lauria|first21=Francesco|last22=Lozanski|first22=Gerard|last23=Montserrat|first23=Emili|last24=Parikh|first24=Sameer A.|last25=Park|first25=Jae H.|last26=Polliack|first26=Aaron|last27=Quest|first27=Graeme R.|last28=Rai|first28=Kanti R.|last29=Ravandi|first29=Farhad|last30=Robak|first30=Tadeusz|last31=Saven|first31=Alan|last32=Seymour|first32=John F.|last33=Tadmor|first33=Tamar|last34=Tallman|first34=Martin S.|last35=Tam|first35=Constantine|last36=Tiacci|first36=Enrico|last37=Troussard|first37=Xavier|last38=Zent|first38=Clive S.|last39=Zenz|first39=Thorsten|last40=Zinzani|first40=Pier Luigi|last41=Falini|first41=Brunangelo|title=Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia|journal=Blood|volume=129|issue=5|year=2017|pages=553–560|issn=0006-4971|doi=10.1182/blood-2016-01-689422}}</ref>
:* [[Annexin A1]] +ve
:* [[Annexin A1]] +ve
:* [[CD20]] +ve
:* [[CD20]] +ve
Line 32: Line 32:


===Flow Cytometry===
===Flow Cytometry===
* On flow cytometry, characteristic findings of hairy cell leukemia include:
* On flow cytometry, characteristic findings of hairy cell leukemia include:<ref name="GreverAbdel-Wahab2017">{{cite journal|last1=Grever|first1=Michael R.|last2=Abdel-Wahab|first2=Omar|last3=Andritsos|first3=Leslie A.|last4=Banerji|first4=Versha|last5=Barrientos|first5=Jacqueline|last6=Blachly|first6=James S.|last7=Call|first7=Timothy G.|last8=Catovsky|first8=Daniel|last9=Dearden|first9=Claire|last10=Demeter|first10=Judit|last11=Else|first11=Monica|last12=Forconi|first12=Francesco|last13=Gozzetti|first13=Alessandro|last14=Ho|first14=Anthony D.|last15=Johnston|first15=James B.|last16=Jones|first16=Jeffrey|last17=Juliusson|first17=Gunnar|last18=Kraut|first18=Eric|last19=Kreitman|first19=Robert J.|last20=Larratt|first20=Loree|last21=Lauria|first21=Francesco|last22=Lozanski|first22=Gerard|last23=Montserrat|first23=Emili|last24=Parikh|first24=Sameer A.|last25=Park|first25=Jae H.|last26=Polliack|first26=Aaron|last27=Quest|first27=Graeme R.|last28=Rai|first28=Kanti R.|last29=Ravandi|first29=Farhad|last30=Robak|first30=Tadeusz|last31=Saven|first31=Alan|last32=Seymour|first32=John F.|last33=Tadmor|first33=Tamar|last34=Tallman|first34=Martin S.|last35=Tam|first35=Constantine|last36=Tiacci|first36=Enrico|last37=Troussard|first37=Xavier|last38=Zent|first38=Clive S.|last39=Zenz|first39=Thorsten|last40=Zinzani|first40=Pier Luigi|last41=Falini|first41=Brunangelo|title=Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia|journal=Blood|volume=129|issue=5|year=2017|pages=553–560|issn=0006-4971|doi=10.1182/blood-2016-01-689422}}</ref>
:* [[CD19]] +ve
:* [[CD19]] +ve
:* [[CD11c]] +ve
:* [[CD11c]] +ve

Revision as of 17:31, 16 November 2018

Hairy cell leukemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hairy cell leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hairy cell leukemia laboratory tests On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Hairy cell leukemia laboratory tests

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hairy cell leukemia laboratory tests

CDC on Hairy cell leukemia laboratory tests

Hairy cell leukemia laboratory tests in the news

Blogs on Hairy cell leukemia laboratory tests

Directions to Hospitals Treating Hairy cell leukemia

Risk calculators and risk factors for Hairy cell leukemia laboratory tests

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of hairy cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like cytoplasmic extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia.

Laboratory Findings

Laboratory findings consistent with the diagnosis of hairy cell leukemia include:[1][2][3]

Complete Blood Count

Blood Smear

  • Hairy cells with thread-like cytoplasmic extensions[5]
  • Positive TRAP stain

Immunohistochemistry

  • On immunohistochemistry, characteristic findings of hairy cell leukemia include:[6]

Flow Cytometry

  • On flow cytometry, characteristic findings of hairy cell leukemia include:[7]

References

  1. ↑ Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.
  2. ↑ Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V (April 1994). "Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia". Leuk. Lymphoma. 13 (3–4): 307–16. doi:10.3109/10428199409056295. PMID 7519510.
  3. ↑ Golomb HM, Catovsky D, Golde DW (November 1978). "Hairy cell leukemia: a clinical review based on 71 cases". Ann. Intern. Med. 89 (5 Pt 1): 677–83. PMID 717940.
  4. ↑ Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.
  5. ↑ Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.
  6. ↑ Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.
  7. ↑ Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Hairy_cell_leukemia_laboratory_tests&oldid=1503599"