Mantle cell lymphoma laboratory findings

Mantle cell lymphoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Mantle cell lymphoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
Staging
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Interventions
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Mantle cell lymphoma laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Mantle cell lymphoma laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Mantle cell lymphoma laboratory findings
on Mantle cell lymphoma laboratory findings
Mantle cell lymphoma laboratory findings in the news
Blogs on Mantle cell lymphoma laboratory findings
Directions to Hospitals Treating Mantle cell lymphoma
Risk calculators and risk factors for Mantle cell lymphoma laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

Laboratory tests for mantle cell lymphoma include complete blood count (CBC), blood chemistry studies, cytogenetic analysis, flow cytometry, immunohistochemistry, genetic testing, FISH, PCR, and immunophenotyping.

Laboratory tests

Laboratory tests for mantle cell lymphoma include:

• Complete blood count (CBC) with differential count
• Blood chemistry studies
• Cytogenetic analysis
• Flow cytometry
• Immunohistochemistry
• Genetic testing

• Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
• Overexpression CYCLIN D mRNA
• Mutation or deletions of ATM gene

• FISH (fluorescence in situ hybridization)
• PCR

• Polymerase chain reaction (PCR) and CER3 clonotypic primers are additional methods, but are less often used.

• Immunophenotyping

• BCL6-, CD5+, CD10-, CD23- (or weakly positive), CD43+, FMC7+