Mantle cell lymphoma laboratory findings: Difference between revisions
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{{CMG}}; {{AE}} {{Akram}} {{AS}} | {{CMG}}; {{AE}} {{Akram}} {{AS}} | ||
==Overview== | ==Overview== | ||
Laboratory tests for mantle cell lymphoma include [[complete blood count]] (CBC), | Laboratory tests for mantle cell lymphoma include [[complete blood count]] (CBC), comprehensive metabolic panel, LDH levels, Hepatitis B testing if treatment with rituximab is planned, uric acid levels, beta-2-microglobulin, pregnancy testing in woman of child-bearing age, [[flow cytometry]], [[immunohistochemistry]], [[genetic testing]], [[FISH]] and [[PCR]] | ||
==Laboratory tests== | ==Laboratory tests== | ||
Laboratory tests for mantle cell lymphoma include: | Laboratory tests for mantle cell lymphoma include: | ||
* [[Complete blood count]] (CBC) with differential count | * [[Complete blood count]] (CBC) with differential count | ||
* | * Comprehensive metabolic panel | ||
* | * LDH levels | ||
* Hepatitis B testing if treatment with rituximab is planned | |||
* Uric acid levels | |||
* Beta-2-microglobulin | |||
* Pregnancy testing in woman of child-bearing age | |||
* [[Flow cytometry]] | * [[Flow cytometry]] | ||
* Immunohistochemistry | * Immunohistochemistry | ||
:* CD19, CD20, CD22, CD43, CD79a, CD5, and FMC7 typically are positive, whereas CD23, CD10, CD200, and BCL6 are usually negative | |||
:* Overexpression of CYCLIN D | |||
:* SOX11 expression | |||
* [[Genetic testing]] | * [[Genetic testing]] | ||
:* Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases | :* Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases | ||
:* Mutation or deletions of ''ATM gene'' | :* Mutation or deletions of ''ATM gene'' | ||
* [[FISH]] (fluorescence in situ hybridization) | * [[FISH]] (fluorescence in situ hybridization) | ||
* [[PCR]] | * [[PCR]] | ||
:*[[Polymerase chain reaction]] (PCR) and CER3 clonotypic primers are additional methods, but are less often used. | :*[[Polymerase chain reaction]] (PCR) and CER3 clonotypic primers are additional methods, but are less often used. | ||
Revision as of 16:19, 18 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
Laboratory tests for mantle cell lymphoma include complete blood count (CBC), comprehensive metabolic panel, LDH levels, Hepatitis B testing if treatment with rituximab is planned, uric acid levels, beta-2-microglobulin, pregnancy testing in woman of child-bearing age, flow cytometry, immunohistochemistry, genetic testing, FISH and PCR
Laboratory tests
Laboratory tests for mantle cell lymphoma include:
- Complete blood count (CBC) with differential count
- Comprehensive metabolic panel
- LDH levels
- Hepatitis B testing if treatment with rituximab is planned
- Uric acid levels
- Beta-2-microglobulin
- Pregnancy testing in woman of child-bearing age
- Flow cytometry
- Immunohistochemistry
- CD19, CD20, CD22, CD43, CD79a, CD5, and FMC7 typically are positive, whereas CD23, CD10, CD200, and BCL6 are usually negative
- Overexpression of CYCLIN D
- SOX11 expression
- Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
- Mutation or deletions of ATM gene
- Polymerase chain reaction (PCR) and CER3 clonotypic primers are additional methods, but are less often used.