Mantle cell lymphoma diagnostic study of choice: Difference between revisions
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==== Fluorescence in situ hybridization (FISH) ==== | ==== Fluorescence in situ hybridization (FISH) ==== | ||
* FISH can be used to detect the translocation t(11;14), which is found in most of MCL patients. | * FISH can be used to detect the translocation t(11;14), which is found in most of MCL patients.<ref>{{Cite journal | ||
| author = [[Tsieh Sun]], [[Mary Lowery Nordberg]], [[James D. Cotelingam]], [[Diana M. Veillon]] & [[John Ryder]] | |||
| title = Fluorescence in situ hybridization: method of choice for a definitive diagnosis of mantle cell lymphoma | |||
| journal = [[American journal of hematology]] | |||
| volume = 74 | |||
| issue = 1 | |||
| pages = 78–84 | |||
| year = 2003 | |||
| month = September | |||
| doi = 10.1002/ajh.10356 | |||
| pmid = 12949897 | |||
}}</ref> | |||
==== Karyotyping: ==== | ==== Karyotyping: ==== | ||
* Karyotyping can also be used to detect the translocation t(11;14), which is found in most of MCL patients. | * Karyotyping can also be used to detect the translocation t(11;14), which is found in most of MCL patients.<ref>{{Cite journal | ||
| author = [[Jordi Camps]], [[Itziar Salaverria]], [[Maria J. Garcia]], [[Esther Prat]], [[Silvia Bea]], [[Jessica C. Pole]], [[Lluis Hernandez]], [[Javier Del Rey]], [[Juan Cruz Cigudosa]], [[Marta Bernues]], [[Carlos Caldas]], [[Dolors Colomer]], [[Rosa Miro]] & [[Elias Campo]] | |||
| title = Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines | |||
| journal = [[Leukemia research]] | |||
| volume = 30 | |||
| issue = 8 | |||
| pages = 923–934 | |||
| year = 2006 | |||
| month = August | |||
| doi = 10.1016/j.leukres.2005.11.013 | |||
| pmid = 16448697 | |||
}}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 21:08, 13 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2]
Overview
Diagnostic Study of Choice
Study of choice
- Tissue biopsy (nodal or extranodal) is the gold standard test for the diagnosis of mantle cell lymphoma.
Histology
- The microscopic histological findings can be found here.
Immunohistochemistry
- CD19, CD20, CD22, CD43, CD79a, CD5, and FMC7 typically are positive, whereas CD23, CD10, CD200, and BCL6 are usually negative.[1][2]
- Cyclin D1 is positive in majority of the cases.
- SOX11 expression may be useful if cyclin D1 is negative.
Fluorescence in situ hybridization (FISH)
- FISH can be used to detect the translocation t(11;14), which is found in most of MCL patients.[3]
Karyotyping:
- Karyotyping can also be used to detect the translocation t(11;14), which is found in most of MCL patients.[4]
References
- ↑ Francesco Bertoni, Emanuele Zucca & Finbarr E. Cotter (2004). "Molecular basis of mantle cell lymphoma". British journal of haematology. 124 (2): 130–140. PMID 14687022. Unknown parameter
|month=ignored (help) - ↑ Chan Yoon Cheah, John F. Seymour & Michael L. Wang (2016). "Mantle Cell Lymphoma". Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34 (11): 1256–1269. doi:10.1200/JCO.2015.63.5904. PMID 26755518. Unknown parameter
|month=ignored (help) - ↑ Tsieh Sun, Mary Lowery Nordberg, James D. Cotelingam, Diana M. Veillon & John Ryder (2003). "Fluorescence in situ hybridization: method of choice for a definitive diagnosis of mantle cell lymphoma". American journal of hematology. 74 (1): 78–84. doi:10.1002/ajh.10356. PMID 12949897. Unknown parameter
|month=ignored (help) - ↑ Jordi Camps, Itziar Salaverria, Maria J. Garcia, Esther Prat, Silvia Bea, Jessica C. Pole, Lluis Hernandez, Javier Del Rey, Juan Cruz Cigudosa, Marta Bernues, Carlos Caldas, Dolors Colomer, Rosa Miro & Elias Campo (2006). "Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines". Leukemia research. 30 (8): 923–934. doi:10.1016/j.leukres.2005.11.013. PMID 16448697. Unknown parameter
|month=ignored (help)